Evidence map›Paper›PMID 39734543›Full record

ReviewFundamental research2024

Non-small-molecule therapeutics for drug addiction: From pharmaco-kinetics modulating to synthetic biology.

Yuanpeng Li, Yibo Wang, Lin Lu, Jie Shi, Xiaohui Wang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Fundamental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuanpeng LiLaboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Yibo WangLaboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Lin LuInstitute of Mental Health, Peking University Sixth Hospital and National Clinical Research Center for Mental Disorders, Peking University, Beijing 100191, China.
Jie ShiNational Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing 100191, China.
Xiaohui WangLaboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug addiction is a pervasive problem worldwide. It not only affects the abuser's life, but also poses a serious threat to public health. Accordingly, there is a strong demand for the development of novel and effective therapies for drug addiction. Considering that small-molecule drugs have only had limited success, there is great interest in developing alternative strategies that extend the reach of small-molecule-based therapies. The antibody-based trapping approach and the enzyme catalytic strategy have been considered as promising ways to reduce the euphoria of drug users by altering drug pharmacokinetics and decreasing drug concentrations in the central nervous system. However, these biological macromolecules are generally unstable and their

Indexed as

Drug abuseEnzymatic degradationGene therapyPharmacokineticsSynthetic biology

Identifiers

PMID39734543
PMCPMC11670666

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.