Evidence map›Paper›PMID 39734403›Full record

ArticleFrontiers in pharmacology2024

Attenuation of neutrophil adhesion and formation of neutrophil extracellular traps by pooled human immune globulins.

Vidhya R Rao, Sana Iqbal, Bradford A Young, Christine Mun, Sandeep Jain, Simon Kaja

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vidhya R Rao *Department of Ophthalmology, Loyola University Chicago, Maywood, IL, United States.
Sana Iqbal *Graduate Program in Molecular Pharmacology and Therapeutics, Loyola University Chicago, Maywood, IL, United States.
Bradford A YoungB.A.Y. Biotech Consulting, Annapolis, MD, United States.
Christine MunOphthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL, United States.
Sandeep JainOphthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL, United States.
Simon KajaDepartment of Ophthalmology, Loyola University Chicago, Maywood, IL, United States.

Funding

Immunotherapy for Ocular Surface DiseasesR24EY032440 · NEI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI JAIN, SANDEEP · 2021 to 2025
$8.3M
NEI NIH HHS R24 EY032440
6 · The paper itself

Abstract

Introduction: This study investigated the efficacy of pooled human immune globulins (Flebogamma Methods: Human neutrophils were isolated by bead-based immunomagnetic depletion of non-target cells from human whole blood. NETosis was induced using phorbol 12-myristate 13-acetate (PMA) or anti-citrullinated histone 4 R3 antibody (H4R3 ACPA). Extracellular DNA was used as a surrogate biomarker of NETosis, and it was quantified using a 96-well, plate reader-based fluorescent assay and by confocal microscopy in 8-well chambers using the DNA dye, SYTOX Results: Pooled human immune globulins (Flebogamma Discussion: These findings show the dose-dependent efficacy of pooled human immune globulins, specifically Flebogamma

Indexed as

anti-citrullinated protein autoantibodiesdry eye diseaseneutrophil extracellular trapocular surface diseasepooled human immune globulin

Identifiers

PMID39734403
PMCPMC11672200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.