Evidence map›Paper›PMID 39734325›Full record

ArticleAnaesthesia2025

Genome-wide association study on chronic postsurgical pain after abdominal surgeries in the UK Biobank.

Song Li, Masja K Toneman, Judith P M Mangnus, Stefano Strocchi, Regina L M van Boekel, Kris C P Vissers, Richard P G Ten Broek, Marieke J H Coenen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Song LiDepartment of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-1429-3161
Masja K TonemanDepartment of Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-2674-0635
Judith P M MangnusDepartment of Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0009-0000-1470-6838
Stefano StrocchiDepartment of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0009-0002-8879-6156
Regina L M van BoekelDepartment of Anesthesiology, Pain and Palliative Medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-0962-2944
Kris C P VissersDepartment of Anesthesiology, Pain and Palliative Medicine, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-2919-6356
Richard P G Ten BroekDepartment of Surgery, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-4012-7968
Marieke J H CoenenDepartment of Clinical Chemistry, Erasmus Medical Center, Rotterdam, The Netherlands.

Funding

China Scholarship Council 201908130179
6 · The paper itself

Abstract

introductionChronic pain is one of the most common and severe complications after surgery, affecting quality of life and overall wellbeing of patients. Several risk factors have been identified but the mechanisms of chronic postsurgical pain development remain unclear. This study aimed to identify single-nucleotide polymorphisms associated with developing chronic postsurgical pain after abdominal surgery, one of the most common types of surgery.

methodsA genome-wide association study was performed on 27,603 patients from the UK Biobank who underwent abdominal surgery. The robustness of identified loci was validated by split-half validation analysis. Functionally related top loci were selected for expression validation in clinical samples of adhesions from patients with and without pain.

resultsOne locus (rs185545327) reached genome-wide significance for association with chronic postsurgical pain development, and 10 loci surpassed the suggestively significant threshold (p < 1 × 10 DISCUSSION: This study provides preliminary evidence for genetic risk factors implicated in chronic postsurgical pain following abdominal surgery, particularly the PDE4D gene, which has been associated with pain in previous studies. The findings add to evidence suggesting potential for the future development of a clinically applicable tool for personalised risk prediction, aiding clinicians in stratifying patients and enhancing clinical decision-making through individualised risk assessments.

Indexed as

AbdomenChronic PainGenome-Wide Association StudyPostoperative PainAdultAgedBiological Specimen BanksFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideUK BiobankUnited Kingdomabdominal surgerychronic postsurgical paingeneticsgenome‐wide association studyUK Biobank

Identifiers

PMID39734325
PMCPMC11987778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.