ArticleMagnetic resonance in medicine2025
Diffusion time effects over the adult lifespan indicates persistent zone-specific microstructural alterations in the human prostate with aging.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Restriction-Weighted Q-Space Trajectory Imaging (ResQ): Toward Mapping Diffusion-Time Effects With Tensor-Valued Diffusion Encoding in Human Prostate Cancer Xenografts.NMR in biomedicine · 2026Article
- Microstructure imaging of prostate cancer by diffusion MRI.Magma (New York, N.Y.) · 2026Review
- Diffusion time effects over the adult lifespan indicates persistent zone-specific microstructural alterations in the human prostate with aging.Magnetic resonance in medicine · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
purposeThe purpose of this study was to investigate microstructural changes in the aging adult prostate by comparing the effects of varying diffusion times using diffusion MRI, and to provide an age-related benchmark for future prostate cancer studies.
methodsThe prostates of normal male volunteers (n = 70, 19-69 years) were scanned at 3 T with an oscillating gradient spin echo (OGSE: 6 ms), pulsed gradient spin echo (PGSE: 40 ms) and pulsed gradient stimulated echo (PGSTE: 100 ms), and anatomical T
resultsPZ and TZ showed quadratic age trajectories for all diffusion scans, with MD decreasing from 19 years to a minimum ˜30-40 years followed by a greater increase at older ages. Short (OGSE) and medium (PGSE) diffusion time MD had similar age trajectories, whereas long diffusion time (PGSTE) MD was significantly lower, particularly in PZ (22%). MD difference (∆MD) of OGSE-PGSTE and PGSE-PGSTE showed significant positive linear correlations with age for both PZ (larger slope) and TZ, resulting in ˜3.3x (PZ) and 1.8x (TZ) greater ∆MD from 19 to 69 years. MD and ∆MD versus age relationships differed from volume, which conversely had greater proportional growth in TZ than PZ.
conclusionThe diffusion time effects suggest age-related microstructural changes consistent with development of persistently larger cell dimensions mainly in the prostate peripheral zone over the adult lifespan. This normative data can be used for comparison to prostate cancer factoring in age.
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