Evidence map›Paper›PMID 39733804›Full record

ArticleJournal of the American Pharmacists Association : JAPhA

Comparative effectiveness of buprenorphine adherence with telemedicine vs. in-person for rural and urban patients.

Thomas J Reese, Nana Addo Padi-Adjirackor, Kevin N Griffith, Bryan Steitz, Stephen W Patrick, Ashley A Leech, Andrew D Wiese, Adam Wright, Mauli V Shah, Jessica S Ancker

Abstract readComparative Study
In one paragraph

Article in Journal of the American Pharmacists Association : JAPhA. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thomas J Reese
Nana Addo Padi-Adjirackor
Kevin N Griffith
Bryan Steitz
Stephen W Patrick
Ashley A Leech
Andrew D Wiese
Adam Wright
Mauli V Shah
Jessica S Ancker

Funding

Optimal Methods for Estimating Policy Effect Heterogeneity in Opioid Policy ResearchP50DA046351 · NIDA · RAND CORPORATION · PI Evan David Peet · 2018 to 2026
$20.8M
Advancing Treatment Outcomes for Pregnant Women with Opioid Use DisorderK01DA050740 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LEECH, ASHLEY A · 2020 to 2024
$860k
Benzodiazepine restrictions and the prevention of overdoses and other harmsK01DA051683 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WIESE, ANDREW DAVID · 2021 to 2024
$688k
AHRQ HHS K08 HS029695NIDA NIH HHS K01 DA050740NIDA NIH HHS K01 DA051683NIDA NIH HHS P50 DA046351
6 · The paper itself

Abstract

backgroundPolicy changes during the COVID-19 pandemic allowed buprenorphine to be prescribed for opioid use disorder via telemedicine without an in-person visit. A recently proposed change will limit buprenorphine access to 30 days without an in-person visit. Given that people living in rural areas may be disproportionally impacted by this change, we sought to better understand how buprenorphine adherence may be impacted by requiring in-person visits.

objectiveCompare buprenorphine adherence after telemedicine to adherence after in-person visits for patients who live in rural and urban areas.

methodsIn this retrospective cohort study, we used electronic health record data from a large medical center. The cohort included all adult patients prescribed buprenorphine for opioid use disorder during 2017-2022. The primary outcome was adherence, characterized by the Medication Possession Ratio (MPR) and gaps in buprenorphine treatment at 30 and 180 days. We conducted a longitudinal analysis at visit level, stratified by patient urbanicity, and controlled for patient, prescriber, prescription, and setting characteristics.

resultsFrom 511 patients, we followed 3302 in-person and 519 telemedicine visits. Compared to in-person visits we observed no difference in the adherence following telemedicine visits overall. However, telemedicine was associated with higher MPR for rural patients (30 days: adjusted marginal effects [AME], 3.7%; 95% CI, 2.0-5.5; P < 0.001 and 180 days: AME, 8.5%; 95% CI 5.7-11.3; P < 0.001) and fewer gaps (30 days: AME, -6.7%; 95% CI, -9.9 to -0.1; P < 0.001 and 180 days: AME, -9.4%; -14.0 to -4.5; P < 0.001) compared to in-person visits.

conclusionThese findings suggest that telemedicine is a viable alternative to in-person visits, especially for patients living in rural areas, which should help guide future policies that preserve or increase access to buprenorphine in a manner that can reduce barriers for patients.

Indexed as

BuprenorphineOpiate Substitution TreatmentOpioid-Related DisordersTelemedicineAdultAnalgesics, OpioidCOVID-19FemaleHumansLongitudinal StudiesMaleMedication AdherenceMiddle AgedRetrospective StudiesRural PopulationUrban PopulationAnalgesics, OpioidBuprenorphine

Identifiers

PMID39733804
PMCPMC11903133

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.