Evidence map›Paper›PMID 39733419›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2024

Toxicity Effect of Hypnea flagelliformis Algae on Cancerous Mitochondria Obtained from Rat Model of Hepatocellular Carcinoma.

Enayatollah Seydi, Mahsa Barzegar, Melika Nazemi, Zhaleh Mohsenifar, Nazanin Shahbazi, Abbas Jafarian-Dehkordi, Jalal Pourahmad

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Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Enayatollah SeydiDepartment of Occupational Health and Safety Engineering, School of Health, Alborz University of Medical Sciences, Karaj, Iran.
Mahsa BarzegarDepartment of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Melika NazemiPersian Gulf and Oman Sea Ecological Research Organization, Iranian Fisheries Research Organization, Agricultural Research, Education and Extension Organization (AREEO) Bandar Abbas, Iran.
Zhaleh MohsenifarDepartment of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nazanin ShahbaziSchool of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
Abbas Jafarian-DehkordiDepartment of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Jalal PourahmadDepartment of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-4555-4168

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectiveHepatocellular carcinoma (HCC) is recognized as one of the major public health problems and deadly malignancies worldwide. Today, the use of compounds of natural origin in the treatment of cancer and other diseases has been of interest to researchers. Marine compounds such as algae have anti-cancer effects. In addition, Sea algae have nutritional value. This research is designed to investigate the cytotoxic effects of Hypnea flagelliformis (H. flagelliformis) extracts (methanolic, diethyl ether and n-hexane) on HCC mitochondria. MATERIAL AND

methodHCC was induced by diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) in rats. Then, toxicity parameters were evaluated.

resultsThe results showed that all H. flagelliformis extracts (250, 500 and 1000 µg/ml) significantly caused toxicity in HCC mitochondria, and no effect on healthy mitochondria was reported.

conclusionThe results indicate that the use of H. flagelliformis along with selected drugs in the treatment of HCC can help in the treatment of this cancer.

Indexed as

Carcinoma, HepatocellularDiethylnitrosamineLiver Neoplasms2-AcetylaminofluoreneAnimalsDisease Models, AnimalLiver Neoplasms, ExperimentalMaleMitochondriaMitochondria, LiverPlant ExtractsRatsRats, WistarRhodophytaSeaweed2-AcetylaminofluoreneDiethylnitrosaminePlant ExtractsCarcinoma HepatocellularHypneaMarine algaemitochondriaModels Animal

Identifiers

PMID39733419
PMCPMC12008340

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.