ArticleAsian Pacific journal of cancer prevention : APJCP2024
Pathologic Features of Rectal Adenocarcinoma after Preoperative Neoadjuvant Chemoradiation Therapy and the Prognostic Factors for Local Recurrence: A Retrospective Study at Maharaj Nakorn Chiang Mai Hospital.
Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer is a significant global health concern, with Thailand reporting notable incidence rates. Locally advanced rectal cancer demands effective treatment strategies to reduce the risk of local recurrence post-surgery; however, the predictive factors for local recurrence are uncertain..
objectiveThis study investigated patients with rectal adenocarcinoma undergoing preoperative concurrent chemoradiation (CCRT). The pathological findings and predictors of local recurrence in rectal adenocarcinoma were examined following preoperative CCRT.
methodsA retrospective cohort study was conducted in patients with rectal adenocarcinoma who underwent preoperative CCRT and surgery at the Maharaj Nakorn Chiang Mai Hospital from January 2018 to December 2022. Data were collected from patients to investigate the associations between pathological prognostic factors and local recurrence of rectal adenocarcinoma. For the analysis of continuous variables, the Student's t-test was employed to assess univariate associations. In the case of categorical variables, comparisons were made using the chi-square test and the Kruskal-Wallis test. Furthermore, the Kaplan-Meier method, supplemented by the log-rank test, was utilized to examine the relationships between baseline prognostic variables and disease-free survival endpoints.
resultsOf the 70 patients who received preoperative CCRT, 14 (20%) experienced recurrence. Univariate log-rank analysis identified five pathologic predictors of the disease-free survival of preoperative CCRT patients: ypT stage (p = 0.0030), lymphatic space invasion (p = 0.0033), venous invasion (p = 0.0345), circumferential resection margin (CRM) (p = 0.0003), and TNM staging (p = 0.0109). In multivariate Cox regression analysis, ypTNM stage and CRM status were independent predictors for disease progression of preoperative CCRT patients.
conclusionypTNM staging and CRM status emerged as independent predictors of local recurrence. The study also identified age and gender variations in rectal cancer incidence, highlighting the importance of tailored screening approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.