Evidence map›Paper›PMID 39733402›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2024

Potential Role of the Tie2/ Angiopoietin System in Hepatitis C Virus- Induced Hepatocellular Carcinoma.

Rabab Fouad, Bothaina Madkour, Manal Zahran, Ali Abdel Rahim, Dalia Salem, Omar Nassar, Shereen Elnashar, Ola Mahmoud

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Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Rabab FouadDepartment of Hematology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.
Bothaina MadkourDepartment of Hematology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.
Manal ZahranDepartment of Hematology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.
Ali Abdel RahimDepartment of Hepato-Gastroenterology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.
Dalia SalemDepartment of Bacteriology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.
Omar NassarDepartment of Obstetrics and Gynecology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
Shereen ElnasharDepartment of Anesthesiology and Intensive Care5, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
Ola MahmoudDepartment of Hematology, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Tie2/Ang pathway was found to be involved in forming tumor blood vessels in various tumors. The goal of this study was to evaluate the value of Tie2/Ang pathway as a novel biomarkers for the early detection of chronic hepatitis C virus (CHC)-related hepatocellular carcinoma (HCC). And the possibility of their future application in HCC treatment.

methodsFlow cytometry was performed to identify and count Tie2 expressing monocytes (TEMs) in peripheral blood monocytes from HCC patients (n = 25), CHC cirrhotic patients (n = 25) and healthy volunteers (n = 25). In addition, Angiopoietin 1 and 2 (Ang) levels in the serum were determined by enzyme linked immunosorbent assay (ELIZA).

resultsPercentage of TEMs in peripheral blood monocytes, serum Ang2 levels and Ang2/Ang1 ratio significantly increased in HCC patients compared with CHC patients and healthy controls (P< 0.001). However significant increase was only noticed in serum Ang1 levels in HCC group compared to the control group (P <0.05).

conclusionsTEMs may promote angiogenesis in HCC regarding the Ang2/Tie2 signal pathway. Percentage of TEMs in peripheral blood monocytes, Ang2 serum levels and Ang2/Ang1 ratio may be applied as a biomarkers for identifying CHC-related HCC. Moreover, inhibiting the proangiogenic functions of this pathway may represent a promising strategy to improve the efficacy of current treatments for HCC.

Indexed as

Angiopoietin-1Angiopoietin-2Carcinoma, HepatocellularHepacivirusLiver NeoplasmsReceptor, TIE-2AdultBiomarkers, TumorCase-Control StudiesFemaleFollow-Up StudiesHepatitis CHepatitis C, ChronicHumansMaleMiddle AgedAngiopoietin-1Angiopoietin-2ANGPT1 protein, humanANGPT2 protein, humanBiomarkers, TumorReceptor, TIE-2TEK protein, humanHCCTEMsTie2/Ang pathway

Identifiers

PMID39733402
PMCPMC12008347

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.