ArticleScientific reports2024
Comparison of the aquatic toxicity of diquat and its metabolites to zebrafish Danio rerio.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Article
- Molecular mechanisms in diquat-induced organs injury：insights into cell signaling and potential therapeutic agents.Cell biology and toxicology · 2025Review
- Diquat based herbicide impair the development and behavior of zebrafish embryos and larvae.Scientific reports · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Diquat (DQ) is a non-selective, fast-acting herbicide that is extensively used in aquatic systems. DQ has been registered as the substitute for paraquat due to its lower toxicity. However, the widespread presence of DQ in aquatic systems can pose an ecological burden on aquatic organisms. In addition, DQ can degrade into its metabolites, diquat-monopyridone (DQ-M) and diquat-dipyridone (DQ-D) in the environment, while the ecological risks of the metabolites remain uncertain. Herein, the aquatic ecological risks of DQ and its metabolites were compared using zebrafish as model non-target organisms. Results indicated that DQ and its metabolites did not induce significant acute toxicity to zebrafish embryos at environmentally relevant levels. However, exposure to DQ and DQ-D resulted in oxidative stress in zebrafish larvae. DQ treatment led to increased levels of reactive oxygen species (ROS), malondialdehyde (MDA), and glutathione (GSH) in the larvae, while DQ-D increased internal MDA and GSH levels. Moreover, the activities of the antioxidative enzymes, superoxide dismutase (SOD) and catalase (CAT) were significantly suppressed by DQ and DQ-D. Besides, the expression levels of oxidative stress-related genes (Mn-SOD, CAT, and GPX) were disturbed accordingly after DQ and DQ-D treatments. These findings highlighted the importance of a more comprehensive understanding of the ecological risks of agrochemical substitutions as well as agrochemical metabolites. Such knowledge is crucial for significant improvements in agrochemical regulation and policy-making in the future.
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Registered trials
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