Evidence map›Paper›PMID 39733007›Full record

ArticleJournal of neurology2024

Expanded and independent validation of the NoMoFA scale for Parkinson's disease: the Italian version.

Roberta Balestrino, Domiziana Rinaldi, Silvia Galli, Alberto Romagnolo, Roberto Erro, Claudia Ledda, Giulia Donzuso, Marina Picillo, Claudio Terravecchia, Federica Agosta and 6 more

Abstract readValidation Study
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Roberta BalestrinoVita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0001-7143-6985
Domiziana RinaldiNESMOS Department, Faculty of Medicine and Psychology, Neurology Unit, Sapienza University of Rome, Sant'Andrea University Hospital, 00189, Rome, Italy.ORCID http://orcid.org/0000-0002-8011-087X
Silvia GalliDepartment of Neurosciences Rita Levi Montalcini, University of Turin, Turin, Italy.ORCID http://orcid.org/0009-0004-2036-4650
Alberto RomagnoloDepartment of Neurosciences Rita Levi Montalcini, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0002-1312-1843
Roberto ErroNeuroscience Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, (Province of Salerno), Italy.ORCID http://orcid.org/0000-0002-7800-7419
Claudia LeddaDepartment of Neurosciences Rita Levi Montalcini, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0003-0839-932X
Giulia DonzusoDepartment of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0003-4925-694X
Marina PicilloNeuroscience Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, (Province of Salerno), Italy.ORCID http://orcid.org/0000-0001-9025-137X
Claudio TerravecchiaDepartment of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Catania, Italy.
Federica AgostaVita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0003-3121-4979
Paolo BaroneNeuroscience Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Baronissi, (Province of Salerno), Italy.ORCID http://orcid.org/0000-0001-8965-2504
Leonardo LopianoDepartment of Neurosciences Rita Levi Montalcini, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0001-9098-387X
Alessandra NicolettiDepartment of Medical, Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, Catania, Italy.ORCID http://orcid.org/0000-0001-6757-340X
Massimo FilippiVita-Salute San Raffaele University, Milan, Italy. filippi.massimo@hsr.it.ORCID http://orcid.org/0000-0002-5485-0479
Pablo Martinez-Martin *Center for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Carlos III Institute of Health, Madrid, Spain.ORCID http://orcid.org/0000-0003-0837-5280
Carlo Alberto Artusi *Department of Neurosciences Rita Levi Montalcini, University of Turin, Turin, Italy.ORCID http://orcid.org/0000-0001-8579-3772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNon-motor symptoms (NMS) in Parkinson's disease (PD) can fluctuate daily, impacting patient quality of life. The Non-Motor Fluctuation Assessment (NoMoFA) Questionnaire, a recently validated tool, quantifies NMS fluctuations during ON- and OFF-medication states. Our study aimed to validate the Italian version of NoMoFA, comparing its results to the original validation and further exploring its clinimetric properties.

methodsThe scale underwent translation, back-translation, and cognitive pretesting before being administered to a calculated sample of > 200 PD patients. Each patient was assessed using a set of validated measures for assessing PD and cognitive state. We explored NoMoFA's feasibility, acceptability, factorial structure, internal consistency, convergent validity, test-retest reliability (the latter performed on 50 patients after 14 days), and the precision of the scale.

results227 PD patients (mean age 65.34, disease duration 9.31 years) were included, with 100% data computability. The scale was free from floor and ceiling effects, and included 7 factors (59.2% of the variance). Cronbach's alpha coefficient was 0.89, indicating strong internal consistency. The intraclass correlation coefficient (ICC) of 0.90 demonstrated satisfactory reproducibility. The NoMoFA Total score showed the strongest correlations with MDS-UPDRS Parts I (r

conclusionThe Italian version of the NoMoFA scale demonstrated strong reliability, validity and precision, making it a robust tool for assessing non-motor fluctuations in PD.

Indexed as

Parkinson DiseaseAgedFemaleHumansItalyMaleMiddle AgedPsychometricsReproducibility of ResultsSeverity of Illness IndexSurveys and QuestionnairesItalian versionNon-Motor Fluctuation Assessment (NoMoFA) QuestionnaireNon-motor fluctuations (NMF)Non-motor symptoms (NMS)Parkinson’s disease (PD)

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.