Evidence map›Paper›PMID 39732948›Full record

Trial reportScientific reports2024

Probiotic treatment induces changes in intestinal microbiota but does not alter SCFA levels in peritoneal dialysis patients-a randomized, placebo-controlled trial.

Shengnan Zhou, Yinyin Yan, Rui Chu, Na Chen, Li Wang, Hongxia Zhang, Yan Wang, Mengting Wang, Li Na, Hongyan Ren and 3 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shengnan Zhou *Department of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Yinyin Yan *Department of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Rui ChuDepartment of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Na ChenDepartment of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Li WangDepartment of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Hongxia ZhangDepartment of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Yan WangDepartment of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Mengting WangDepartment of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Li NaBioBank of General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Hongyan RenShanghai Mobio Biomedical Technology Co. Ltd., Shanghai, 201100, China.
Menghua ChenDepartment of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.
Philip Kam-Tao LiDepartment of Medicine and Therapeutics, Carol and Richard Yu Peritoneal Dialysis Research Centre, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China. philipli@cuhk.edu.hk.
Na TianDepartment of Nephrology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China. tianna@nxmu.edu.cn.

Funding

Key R&D Projects in Ningxia Autonomous Region 2022BEG03120National Natural Science Foundation of China No. 81960144&82360153Natural Science Foundation of Ningxia Province 2022AAC02062Natural Science Foundation Project of The Second Affiliated Hospital of Xi'an Medical University 23KY0122
6 · The paper itself

Abstract

The gut microbiota alterations interact with the pathogenesis and progression of chronic kidney disease (CKD). Probiotics have received wide attention as a potential management in CKD. We investigated the effects of Lactobacillus paracasei N1115 (LP N1115) on intestinal microbiota and related short-chain fatty acids (SCFAs) in end stage kidney disease patients on peritoneal dialysis (PD) in a single-center, prospective, randomized, double-blind, placebo-controlled study. The patients were randomly allocated into two groups. The intervention group (n = 38, PR group) was given the probiotics (two bags) containing fructooligosaccharide (FOS) (additive amount > 80%), maltosaccharin, and LP N1115 (additive amount > 3 × 10

Indexed as

Fatty Acids, VolatileGastrointestinal MicrobiomePeritoneal DialysisProbioticsAdultAgedDouble-Blind MethodFecesFemaleHumansKidney Failure, ChronicLacticaseibacillus paracaseiMaleMiddle AgedOligosaccharidesProspective StudiesFatty Acids, VolatilefructooligosaccharideOligosaccharidesRNA, Ribosomal, 16S

Identifiers

PMID39732948
PMCPMC11682217

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.