ArticleScientific reports2024
Tissue growth as a mechanism for collagen fiber alignment in articular cartilage.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- From microtissues to macro solutions - The future of scalable and automated cartilage tissue engineering.Journal of orthopaedic translation · 2026Review
- Synchronizing the Osteochondral Regeneration Process through Spatial Patterning of Stable and Hypertrophic Cartilage Organoids.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Step-Ladder Bioprinting to Align Collagen Fibers for Anisotropic Tissue Fabrication.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Zone-inspired hydrogel constructs promote spatially controlled chondrogenesis for osteochondral regeneration.Scientific reports · 2025Article
- Insights of cartilage imaging in cartilage regeneration.World journal of orthopedics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Articular cartilage is distinguished by the unique alignment of type II collagen, a feature crucial for its mechanical properties and function. This characteristic organization is established during postnatal development of the tissue, yet the underlying mechanisms remain poorly understood. In this study, a potential mechanism for type II collagen alignment by cartilage-specific growth from within the tissue was investigated. Bovine chondrocyte-derived cartilage organoids were cultured in a transwell system, subjecting the created tissue to transforming growth factor β1 stimulation from either the bottom (bottom-up) or the top (top-down) compartment to induce interstitial growth and appositional growth, respectively. The results demonstrate that interstitial growth within the tissue, stimulated from underneath, successfully produced aligned type II collagen parallel to the direction of this growth. In contrast, appositional growth did not yield such alignment. These findings underscore the critical role of the direction of growth in recreating the characteristic collagen organization of articular cartilage, offering valuable insights for the advancement of creating functional tissue in tissue engineering strategies.
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Registered trials
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