Evidence map›Paper›PMID 39732859›Full record

ArticleScientific reports2024

Comprehension of acoustically degraded emotional prosody in Alzheimer's disease and primary progressive aphasia.

Jessica Jiang, Jeremy C S Johnson, Maï-Carmen Requena-Komuro, Elia Benhamou, Harri Sivasathiaseelan, Anthipa Chokesuwattanaskul, Annabel Nelson, Ross Nortley, Rimona S Weil, Anna Volkmer and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Musicality is Preserved in Neurodegeneration.The Yale journal of biology and medicine · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jessica JiangDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK.
Jeremy C S JohnsonDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK.
Maï-Carmen Requena-KomuroDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK.
Elia BenhamouDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK.
Harri SivasathiaseelanDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK.
Anthipa ChokesuwattanaskulDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK.
Annabel NelsonDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK.
Ross NortleyDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK.
Rimona S WeilDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK.
Anna VolkmerDivision of Psychology and Language Sciences, University College London, London, UK.
Charles R MarshallCentre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
Doris-Eva BamiouUCL Ear Institute and UCL/UCLH Biomedical Research Centre, National Institute of Health Research, University College London, London, UK.
Jason D Warren *Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK.
Chris J D Hardy *Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1st Floor, 8-11 Queen Square, London, WC1N 3AR, UK. chris.hardy@ucl.ac.uk.

Funding

Alzheimer's Society 627Alzheimer's Society AS-PG-16-007Association of British Neurologists Clinical Research Training FellowshipBrain Research UK PhD StudentshipDunhill Medical Trust PA23Leonard Wolfson Experimental Neurology Centre Clinical Research FellowshipNational Brain Appeal Frontotemporal Dementia Research Studentship in Memory of David BlechnerNational Institute for Health and Care Research NIHR204280National Institute for Health and Care Research NIHR302240Royal National Institute for Deaf People G105Wellcome TrustWellcome Trust 102129/B/13/zWellcome Trust 205167/Z/16/Z
6 · The paper itself

Abstract

Previous research suggests that emotional prosody perception is impaired in neurodegenerative diseases like Alzheimer's disease (AD) and primary progressive aphasia (PPA). However, no previous research has investigated emotional prosody perception in these diseases under non-ideal listening conditions. We recruited 18 patients with AD, and 31 with PPA (nine logopenic (lvPPA); 11 nonfluent/agrammatic (nfvPPA) and 11 semantic (svPPA)), together with 24 healthy age-matched individuals. Participants listened to speech stimuli conveying three emotions in clear and noise-vocoded forms and had to identify the emotion being conveyed. We then conducted correlation analyses between task performance and measures of socio-emotional functioning. All patient groups showed significant impairments in identifying clear emotional prosody compared to healthy individuals. These deficits were exacerbated under noise-vocoded conditions, with all patient groups performing significantly worse than healthy individuals and patients with lvPPA performing significantly worse than those with svPPA. Significant correlations with social cognition measures were observed more consistently for noise-vocoded than clear emotional prosody comprehension. These findings open a window on a dimension of real-world emotional communication that has often been overlooked in dementia, with particular relevance to social cognition, and begin to suggest a novel candidate paradigm for investigating and quantifying this systematically.

Indexed as

Alzheimer DiseaseAphasia, Primary ProgressiveComprehensionEmotionsSpeech PerceptionAgedAged, 80 and overCase-Control StudiesFemaleHumansMaleMiddle AgedAlzheimer’s diseaseDegraded speechDementiaEmotional prosodyFrontotemporal dementiaNoise-vocodingPrimary progressive aphasiaSocial cognition

Identifiers

PMID39732859
PMCPMC11682080

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.