ArticleScientific reports2024
Effects of minipuberty disruption on the expression of sexual behavior in female mice.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Sex steroids influence early organization of neural structures involved in expression of sexual behavior. A critical perinatal period during which testosterone surges occur has been identified in male rodents. Data are lacking for females, whose ovarian activity starts later in the postnatal period. Minipuberty has been described in female as a first postnatal period of gonadotropic axis activation. We transiently disrupted the minipubertal period, using daily injections of GnRH antagonist or aromatase inhibitor. The results showed unchanged puberty initiation and mild disturbance of estrus cyclicity. Minor modifications of some components of sexual behavior (olfactory preference, ability to attract male) were observed, but had no impact on lordosis behavior. Interestingly, letrozole-treated female mice showed increased anxiety state level at adulthood. This period therefore does not seem to be a key organizational window for female sexual behavior but appears to participate in the organization of neural structures involved in anxiety-related behavior.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.