Evidence map›Paper›PMID 39732801›Full record

ArticleScientific reports2024

New class of thio/semicarbazide-based benzyloxy derivatives as selective class of monoamine oxidase-B inhibitors.

Namitha Chandran, Jiseong Lee, Prabitha Prabhakaran, Sunil Kumar, Sachithra Thazhathuveedu Sudevan, Della Grace Thomas Parambi, Tariq G Alsahli, Manu Pant, Hoon Kim, Bijo Mathew

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Namitha Chandran *Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India.
Jiseong Lee *Department of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, 57922, Republic of Korea.
Prabitha PrabhakaranDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research Mysuru, Mysuru, 570015, India.
Sunil KumarDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India.
Sachithra Thazhathuveedu SudevanDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India.
Della Grace Thomas ParambiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, 72341, Sakaka, Aljouf, Saudi Arabia.
Tariq G AlsahliDepartment of Pharmacology, College of Pharmacy, Jouf University, 72341, Sakaka, Aljouf, Saudi Arabia.
Manu PantDepartment of Biotechnology, Graphic Era (Deemed to be university), Clement town, Dehradun, 248002, India.
Hoon KimDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, 57922, Republic of Korea. hoon@sunchon.ac.kr.
Bijo MathewDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India. bijomathew@aims.amrita.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sixteen thio/semicarbazide-based benzyloxy derivatives (BT1-BT16) were synthesized and evaluated for their inhibitory activities against monoamine oxidases (MAOs). Most compounds showed better inhibitory activity against MAO-B than against MAO-A. BT1, BT3, and BT5 showed the greatest inhibitory activity with an identical IC

Indexed as

Monoamine OxidaseMonoamine Oxidase InhibitorsSemicarbazidesBlood-Brain BarrierHumansKineticsMolecular Docking SimulationNeuroprotective AgentsStructure-Activity RelationshipSuperoxide DismutaseMonoamine OxidaseMonoamine Oxidase InhibitorsNeuroprotective AgentsSemicarbazidesSuperoxide DismutaseBenzyloxy benzene-based thio/Semicarbazide derivativesKineticsMolecular dynamicsMonoamine oxidaseReversibility

Identifiers

PMID39732801
PMCPMC11682371

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.