ArticleScientific reports2024
Antifungal activity of essential oils and their potential synergistic effect with amphotericin B.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Trial
- [Preparation of Lip-TTO-PHMB and evaluation of itsZhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- Current Knowledge of the GenusPharmaceuticals (Basel, Switzerland) · 2026Review
- Pogostone disrupts key virulence traits of Candida albicans: hyphal inhibition and biofilm suppression.BMC microbiology · 2026Article
- Essential oils as nature-engineered antifungals: a comprehensive review of pharmacological mechanisms, drug synergism, and advanced formulation strategies.Frontiers in pharmacology · 2026Review
- TargetingInternational journal of molecular sciences · 2025Article
- Unraveling the Effects ofInternational journal of molecular sciences · 2025Review
- The Potential ofPharmaceutics · 2025Article
- Essential Oils and their Active Constituents Effective against Non-growing Mycobacterium intracellulare.BMC complementary medicine and therapies · 2025Article
- Amplicon Analysis of Dictean Cave Microbial Communities and Essential Oils as a Mild Biocide.Microbes and environments · 2025Article
- Antifungal activity and mechanism ofFrontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Candida albicans is a common opportunistic pathogen, causing infections ranging from superficial to bloodstream infections. The limited antifungal options and rising drug resistance challenge clinical treatment. We screened 98 essential oils and identified 48 with antifungal activity against Candida albicans at 1% concentration, determining their minimum inhibitory concentrations (MIC). Of these, 14 maintained fungicidal activity at lower concentrations (0.25% and 0.125%). 5 essential oils (Cinnamon, Satureja montana, Palmarosa, Lemon eucalyptus, and Honey myrtle) showed the highest inhibitory effects on stationary-phase Candida albicans and inhibited hyphae elongation. Synergistic effects were observed when combining Palmarosa with amphotericin B (AmB) against growing-phase Candida albicans, while Cinnamon and Satureja montana with AmB showed superior efficacy against stationary-phase infections. We identified the active components of 5 essential oils using gas chromatography-mass spectrometry (GC-MS) and found the following main constituents: Cinnamon primarily contains benzyl benzoate and eugenol, Satureja montana is dominated by carvacrol and cymene, Palmarosa features geraniol and geranyl acetate, Lemon eucalyptus includes dl-Isopulegol and citronellal, and Honey myrtle is characterized by citral and neral. Our results may aid in developing more effective antifungal treatments.
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