Evidence map›Paper›PMID 39732698›Full record

ArticleBMC veterinary research2024

Four SNPs in the untranslated region of the NOTCH2 gene involved in reproductive traits in fertile and anestrum Holstein Friesian cattle.

Karima Gh M Mahmoud, Ahmed S A Sosa, Hassan R H Darwish, Sally Ibrahim, Mahmoud H Hasanain, Essam A Almadaly, Abdelaziz M Sakr, A Sh E Shams, Daniela Elena Ilie

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Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Karima Gh M MahmoudDepartment of Animal Reproduction& AI, National Research Centre, Tahrir Street, Dokki, Giza, 12622, Egypt. karimamahmoud@yahoo.com.ORCID http://orcid.org/0000-0002-0482-1207
Ahmed S A SosaDepartment of Animal Reproduction& AI, National Research Centre, Tahrir Street, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0001-9726-2936
Hassan R H DarwishCell Biology Department and A.I, Institute of Biotechnology Research, National Research Centre, Dokki, 12622, Giza, Egypt.ORCID http://orcid.org/0000-0001-9141-2278
Sally IbrahimDepartment of Animal Reproduction& AI, National Research Centre, Tahrir Street, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0003-2098-6463
Mahmoud H HasanainDepartment of Animal Reproduction& AI, National Research Centre, Tahrir Street, Dokki, Giza, 12622, Egypt.ORCID http://orcid.org/0000-0002-3283-2309
Essam A AlmadalyDepartment of Theriogenology, Faculty of Veterinary Medicine, Kafrelsheikh University, El-Geish street, Kafrelsheikh, 33516, Egypt.ORCID http://orcid.org/0000-0003-3598-8090
Abdelaziz M SakrDepartment of Biotechnology, Animal Production Research Institute, Agriculture Research Center, Giza, Egypt.ORCID http://orcid.org/0000-0001-6800-1171
A Sh E ShamsDepartment of Animal Nutrition Research, Animal Production Research Institute, Agriculture Research Center, Giza, Egypt.ORCID http://orcid.org/0000-0001-6340-887X
Daniela Elena IlieDepartment of Research, Research and Development Station for Bovine, Arad, Romania.ORCID http://orcid.org/0000-0002-0464-3199

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are no studies belong NOTCH2 gene polymorphism in relation to reproductive and productive traits in Holstein cattle. The objective of the present study was to investigate the effect of NOTCH2 gene polymorphisms on productive and reproductive performance of fertile and anestrum cattle.

methodsThe cattle were classified into anestrus for 3-12 months postpartum (n = 115, 37.7%) and normal cyclic fertile (n = 190, 62.3%). Age at 1st calving, calving interval, calf birth weight, milk yield and days of milking data were obtained from the farm records for all animals. Blood samples were collected from fertile and anestrum animals for DNA extraction and the PCR as well as single-strand conformation polymorphism techniques (SSCP) were performed for detection of the NOTCH2 gene polymorphism.

resultsThe sequencing results showed that NOTCH2 gene in cattle is polymorphic with 5 genotypes AA, AG, GG, CC and CT. Four novel SNPs as transition single base substitution mutations were detected at 3: 23,192,033 (A/G), 3:23192149 (C/T), 3:23192071 (C/T) and 3:23192143 (G/A). GG genotype of NOTCH2 gene was associated with shorter calving interval and heavier calf birth weight in both fertile and anestrum cattle.

conclusionsNOTCH2 gene in cattle could be used as a genetic marker involved in reproductive traits in both fertile and anestrum cattle.

Indexed as

Polymorphism, Single NucleotideReceptor, Notch2AnimalsCattleCattle DiseasesFemaleFertilityGenotypePolymorphism, Single-Stranded ConformationalReproductionReceptor, Notch2FertilityNOTCH2 genePolymorphismProductive traitsSNPs

Identifiers

PMID39732698
PMCPMC11681750

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.