Evidence map›Paper›PMID 39732438›Full record

Trial reportThe Journal of nutrition2025

Mode of Action of Psyllium in Reducing Gas Production from Inulin and its Interaction with Colonic Microbiota: A 24-hour, Randomized, Placebo-Controlled Trial in Healthy Human Volunteers.

Alaa T Alhasani, Amisha A Modasia, Mohamed Anodiyil, Maura Corsetti, Abdulsalam I Aliyu, Colin Crooks, Luca Marciani, Joshua Reid, Gleb E Yakubov, Moira Taylor and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05619341 (Effect of Rate Of Delivery on Colonic Fermentation of inuliN), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05619341 nacompletednot on this map

Effect of Rate Of Delivery on Colonic Fermentation of inuliN (EON)

TypeinterventionalSponsorUniversity of NottinghamRan2022 to 2023Enrolled17ConditionsIrritable BowelArmspsyllium, inulin
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alaa T AlhasaniNottingham NIHR Biomedical Research Centre and Nottingham Digestive Disease Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Faculty of Health and Rehabilitation Sciences, Princess Nourah Bint Abdul Rahman University, Riyadh, Saudi Arabia.
Amisha A ModasiaQuadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Mohamed AnodiyilNottingham NIHR Biomedical Research Centre and Nottingham Digestive Disease Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
Maura CorsettiNottingham NIHR Biomedical Research Centre and Nottingham Digestive Disease Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
Abdulsalam I AliyuNottingham NIHR Biomedical Research Centre and Nottingham Digestive Disease Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
Colin CrooksNottingham NIHR Biomedical Research Centre and Nottingham Digestive Disease Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
Luca MarcianiNottingham NIHR Biomedical Research Centre and Nottingham Digestive Disease Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom.
Joshua ReidFood and Biomaterials Laboratory, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom.
Gleb E YakubovFood and Biomaterials Laboratory, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom.
Moira TaylorFaculty of Medicine & Health Sciences, University of Nottingham Medical School Queen's Medical Centre, Nottingham, UK.
Amanda AveryFood and Biomaterials Laboratory, School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, United Kingdom.
Hannah HarrisQuadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Frederick J WarrenQuadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
Robin C SpillerNottingham NIHR Biomedical Research Centre and Nottingham Digestive Disease Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom. Electronic address: mszrs@exmail.nottingham.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BBS/E/QU/230001BBiotechnology and Biological Sciences Research Council BB/X011054/1Medical Research Council 5954150:I
6 · The paper itself

Abstract

backgroundRecent studies show that the increase in breath hydrogen (BH

objectivesTo determine if slowing delivery of inulin to the colon by administering it in divided doses would mimic the effect of PI. Primary endpoint was the BH

methodsA total of 17 healthy adults were randomly assigned to a single-blind, 3-arm, crossover trial. All consumed 20 g inulin (I) powder dissolved in 500 mL water and mixed with either 20 g maltodextrin (control) or 20 g PI consumed as a single dose or 20 g inulin given in divided doses (DDI), 62.5 mL every 45 min over 6 h. Twenty-four-hour BH

resultsCompared with control, PI did not reduce mean BH

conclusionsDDI, like PI, reduces early BH CLINICALTRIALS: gov as NCT05619341.

Indexed as

ColonGastrointestinal MicrobiomeInulinPsylliumAdultBreath TestsCross-Over StudiesFecesFemaleFermentationHealthy VolunteersHumansHydrogenMaleMiddle AgedSingle-Blind MethodHydrogenInulinPsylliumfermentationFODMAPsinulinmetagenomicsmicrobiotapsylliumwhole gut transit

Identifiers

PMID39732438
PMCPMC11934246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.