Evidence map›Paper›PMID 39732377›Full record

ArticleAlcohol (Fayetteville, N.Y.)2025

Age-related impact of phenobarbital in suppressing prenatal alcohol exposure-related seizures in developing rats.

Tengfei Li, George Luta, Prosper N'Gouemo

Abstract read
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In one paragraph

Article in Alcohol (Fayetteville, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tengfei LiGeorgetown University Medical Center, Department of Biostatistics, Bioinformatics, and Biomathematics, Washington, DC 20057, United States.
George LutaGeorgetown University Medical Center, Department of Biostatistics, Bioinformatics, and Biomathematics, Washington, DC 20057, United States.
Prosper N'GouemoHoward University College of Medicine, Department of Physiology and Biophysics, Washington, DC 20059, United States. Electronic address: prosper.ngouemo@howard.edu.

Funding

Na+/Ca2+ exchanger remodeling in alcohol withdrawal seizuresR01AA027660 · NIAAA · HOWARD UNIVERSITY · PI N'GOUEMO, PROSPER · 2019 to 2023
$1.7M
Pediatric seizures: role of IP3R Ca2+ release channelsR21AA027171 · NIAAA · HOWARD UNIVERSITY · PI N'GOUEMO, PROSPER · 2018 to 2019
$408k
NIAAA NIH HHS R01 AA027660NIAAA NIH HHS R21 AA027171
6 · The paper itself

Abstract

Prenatal alcohol exposure (PAE) during pregnancy can increase the prevalence of N-methyl-d-aspartate (NMDA)-induced generalized tonic-clonic seizures (GTCSs) in developing rats. However, it is unclear whether phenobarbital (PB) can suppress these PAE-related seizures. To explore this knowledge gap, we investigated the effects of acute PB treatment on NMDA-induced seizures in postpartum rats, prenatally exposed to alcohol on gestational day 18 (GD18), at two developmental stages: day 7 (P7), the equivalent of pre-term neonates, and day 15 (P15), the equivalent of full-term neonates. Timed-pregnant female Sprague-Dawley rats were given a single dose of alcohol or its vehicle on GD18 during the second-trimester equivalent. Male and female postpartum rats were tested for the effectiveness of single-dose treatment with either PB or its vehicle in suppressing NMDA-induced seizures. These seizures include wild running-like behavior (WRLB), flexion seizures (FSs), clonic seizures (CSs), generalized tonic-clonic seizures (GTCSs), and tonic seizures (TSs) in P7 and P15 rats. Analyses revealed that P7 rats were more likely to develop GTCSs after PB administration than P15 rats; this effect was associated with shorter latencies to develop NMDA-induced seizures. Moreover, PAE-related seizure severity is less responsive to PB treatment in P7 rats than in P15 rats. These findings suggest that the PAE-related GTCS model in P7 rats can be used to investigate the mechanisms underlying PB-resistant seizures in developing rats.

Indexed as

AnticonvulsantsEthanolPhenobarbitalPrenatal Exposure Delayed EffectsSeizuresAge FactorsAnimalsAnimals, NewbornFemaleMaleN-MethylaspartatePregnancyRatsRats, Sprague-DawleyAnticonvulsantsEthanolN-MethylaspartatePhenobarbitalFlexion seizuresFull-term newbornGeneralized tonic-clonic seizuresGestational alcohol exposureN-methyl-d-aspartatePreterm infant

Identifiers

PMID39732377
PMCPMC12000881

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.