Evidence map›Paper›PMID 39732160›Full record

Observational studyThe Journal of pediatrics2025

Changes in Patent Ductus Arteriosus Management and Outcomes in Infants Born at 26-28 Weeks' Gestation.

Dinushan C Kaluarachchi, Matthew A Rysavy, Barbara T Do, Valerie Y Chock, Matthew M Laughon, Carl H Backes, Tarah T Colaizy, Edward F Bell, Patrick J McNamara

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00063063 (Generic Database), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00063063 recruitingnot on this map

Generic Database: A Survey of Morbidity and Mortality in Very Low Birth Weight Infants

TypeobservationalSponsorNICHD Neonatal Research NetworkRan1987 to 2030Enrolled80,000ConditionsInfant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, PrematureArmsNo Intervention
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dinushan C KaluarachchiDepartment of Pediatrics, University of Wisconsin-Madison, Madison, WI. Electronic address: kaluarachchi@pediatrics.wisc.edu.
Matthew A RysavyDepartment of Pediatrics, McGovern Medical School, UTHealth Houston, Houston, TX.
Barbara T DoBiostatistics and Epidemiology Division RTI International, Research Triangle Park, NC.
Valerie Y ChockDepartment of Pediatrics, Stanford University School of Medicine, Palo Alto, CA.
Matthew M LaughonDepartment of Pediatrics, University of North Carolina, Chapel Hill, NC.
Carl H BackesDepartment of Pediatrics, Ohio State University and Nationwide Children's Hospital, Columbus, OH.
Tarah T ColaizyDepartment of Pediatrics, University of Iowa, Iowa City, IA.
Edward F BellDepartment of Pediatrics, University of Iowa, Iowa City, IA.
Patrick J McNamaraDepartment of Pediatrics, University of Iowa, Iowa City, IA.

Funding

Neonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2M
Neonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3M
Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Data Ctr for the Cooperative Neonatal Research NetworkU01HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 1998 to 2007
$21.8M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021385 · NICHD · WAYNE STATE UNIVERSITY · PI SHANKARAN, SEETHA · 1991 to 2015
$8.7M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027904 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LAPTOOK, ABBOT R · 1991 to 2015
$8.7M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027853 · NICHD · UNIVERSITY OF CINCINNATI · PI SCHIBLER, KURT R · 1991 to 2015
$6.2M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD021373 · NICHD · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI KENNEDY, KATHLEEN A · 1991 to 2015
$6.1M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027856 · NICHD · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SOKOL, GREGORY M. · 1991 to 2015
$5.9M
NICHD Cooperative Multicenter Neonatal Research NetworkU10HD027871 · NICHD · YALE UNIVERSITY · PI EHRENKRANZ, RICHARD A. · 1991 to 2012
$3.9M
NICHD Neonatal Research Network -- Cincinnati Clinical CenterUG1HD027853 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI STEPHANIE L MERHAR · 2016 to 2026
$3.7M
NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1 TR001117NICHD NIH HHS F32 HD098782NICHD NIH HHS L40 HD099827NICHD NIH HHS U01 HD036790NICHD NIH HHS U10 HD021373NICHD NIH HHS U10 HD021385NICHD NIH HHS U10 HD027853NICHD NIH HHS U10 HD027856NICHD NIH HHS U10 HD027871NICHD NIH HHS U10 HD027904NICHD NIH HHS U10 HD036790NICHD NIH HHS U10 HD053119NICHD NIH HHS U10 HD068270NICHD NIH HHS U10 HD068284NICHD NIH HHS U24 HD095254NICHD NIH HHS UG1 HD021364NICHD NIH HHS UG1 HD021385NICHD NIH HHS UG1 HD027851NICHD NIH HHS UG1 HD027853NICHD NIH HHS UG1 HD027856NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD027904NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068244NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD068270NICHD NIH HHS UG1 HD068278NICHD NIH HHS UG1 HD068284NICHD NIH HHS UG1 HD087226NICHD NIH HHS UG1 HD087229NICHD NIH HHS UG1 HD104252NICHD NIH HHS UG1 HD112093
6 · The paper itself

Abstract

objectiveTo investigate the association between the secular decrease in treatment of patent ductus arteriosus (PDA) and trends in neonatal mortality and morbidity in infants born at 26 0/7-28 6/7 weeks' gestation. STUDY

designA retrospective cohort study including infants born between 2012 and 2021 in continually participating hospitals in the National Institute of Child Health and Human Development Neonatal Research Network. The primary composite outcome was defined as surgical necrotizing enterocolitis, grade 2-3 bronchopulmonary dysplasia (BPD), severe intraventricular hemorrhage, or death. Relationships of temporal trends in PDA treatment with the primary composite outcome and its components were analyzed using a multilevel model accounting for patient-level factors. A separate analysis assessed these relationships stratified by hospital changes in PDA treatment.

resultsThe study included 7864 infants. There was a decrease in any PDA treatment from 21% to 16% (P < .01) and an increase in the primary composite outcome from 24% to 36% (P < .01). Change in the primary outcome was driven by increased grade 2-3 BPD (13%-26%, P < .01), with grade 2 BPD accounting for most of this increase (10%-22%, P < .01). Temporal decreases in PDA treatment were associated with increases in the primary outcome and grade 2-3 BPD after adjusting for patient-level factors (P < .01). However, stratified analyses showed that grade 2-3 BPD increased in all hospital groups, regardless of changes in PDA management.

conclusionsFrom 2012 to 2021, temporal decreases in PDA treatment for infants 26-28 weeks were associated with an increase in grade 2-3 BPD. However, caution is warranted in determining causality. Reasons for increased grade 2-3 BPD during the past decade warrant investigation.

trial registrationGeneric Database: NCT00063063.

Indexed as

Ductus Arteriosus, PatentBronchopulmonary DysplasiaEnterocolitis, NecrotizingFemaleGestational AgeHumansInfant, Extremely PrematureInfant MortalityInfant, NewbornMaleRetrospective StudiesTreatment OutcomeUnited Statesbronchopulmonary dysplasiaoutcomespatent ductus arteriosuspreterm infantsecular trends

Identifiers

PMID39732160
PMCPMC11903134

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.