Evidence map›Paper›PMID 39732083›Full record

Trial reportJournal of anxiety disorders2025

Exposure therapy consortium: Outcomes of the proof-of-principle study.

Jasper A J Smits, Jonathan S Abramowitz, Rebecca A Anderson, Joanna J Arch, Daniel Badeja, Snir Barzilay, Amanda N Belanger, Thomas Borchert, Emma Bryant, Alane S Burger and 27 more

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of anxiety disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Jasper A J SmitsDepartment of Psychology, The University of Texas at Austin, USA. Electronic address: smits@utexas.edu.
Jonathan S AbramowitzDepartment of Psychology, The University of North Carolina at Chapel Hill, USA.
Rebecca A AndersonSchool of Population Health and enAble Institute, Curtin University, Australia.
Joanna J ArchDepartment of Psychology and Neuroscience, University of Colorado Boulder, USA.
Daniel BadejaFakultät für Psychologie, Technische Universität Dresden, Germany.
Snir BarzilayDepartment of Psychology, The Hebrew University of Jerusalem, Israel.
Amanda N BelangerDepartment of Psychology, The University of Miami, USA.
Thomas BorchertTranslational Psychotherapy, Institute of Psychology, Georg-August-Universität Göttingen, Germany.
Emma BryantSchool of Psychology, University of New South Wales Sydney and Black Dog Institute, Australia.
Alane S BurgerDepartment of Psychology and Neuroscience, University of Colorado Boulder, USA.
Laura J DixonDepartment of Psychology, University of Mississippi, USA.
Christina D DutcherDepartment of Psychology, The University of Texas at Austin, USA.
Hayley E FitzgeraldDepartment of Psychological and Brain Sciences, Boston University, USA.
Bronwyn M GrahamSchool of Psychology, University of New South Wales Sydney and Black Dog Institute, Australia.
Anke HaberkampFakultät für Psychologie, Universität Witten/Herdecke, Germany.
Stefan G HofmannFakultät für Psychologie, Philipps-Universität Marburg, Germany.
Jürgen HoyerFakultät für Psychologie, Technische Universität Dresden, Germany.
Jonathan D HuppertDepartment of Psychology, The Hebrew University of Jerusalem, Israel.
David JohnsonDepartment of Psychological and Brain Sciences, Texas A&M University, USA.
Baraa Q KabhaDepartment of Psychology, The Hebrew University of Jerusalem, Israel.
Alex KirkDepartment of Psychology and Neuroscience, University of Colorado Boulder, USA.
Jürgen MargrafFakultät für Psychologie, Ruhr-Universität Bochum, Germany.
Peter M McEvoySchool of Population Health and enAble Institute, Curtin University, Australia.
Bryan McSpaddenDepartment of Psychology, The University of Texas at Austin, USA.
Jill NewbySchool of Psychology, University of New South Wales Sydney and Black Dog Institute, Australia.
Michael W OttoDepartment of Psychological and Brain Sciences, Boston University, USA.
Santiago PapiniDepartment of Psychology, University of Hawai'i at Mānoa, USA.
E Marie ParsonsDepartment of Psychological and Brain Sciences, Boston University, USA.
Andre PittigTranslational Psychotherapy, Institute of Psychology, Georg-August-Universität Göttingen, Germany.
Roxana PittigTranslational Psychotherapy, Institute of Psychology, Georg-August-Universität Göttingen, Germany.
Winfried RiefFakultät für Psychologie, Universität Witten/Herdecke, Germany.
Svenja SchaumburgFakultät für Psychologie, Ruhr-Universität Bochum, Germany.
Kiara R TimpanoDepartment of Psychology, The University of Miami, USA.
Lena WaltemateTranslational Psychotherapy, Institute of Psychology, Georg-August-Universität Göttingen, Germany.
Andre WannemüllerFakultät für Psychologie, Ruhr-Universität Bochum, Germany.
Cornelia WeiseInstitut für Psychologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
Exposure Therapy Consortium

Funding

1/2: CO2 Reactivity as a Biomarker of Non-response to Exposure-based TherapyR01MH125951 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI Marie H. Monfils, Jasper Smits · 2022 to 2026
$3.6M
2/2-CO2 Reactivity as a Biomarker of Non-Response to Exposure-Based TherapyR01MH125949 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Michael W. Otto · 2022 to 2026
$2.8M
NIMH NIH HHS R01 MH125949NIMH NIH HHS R01 MH125951Wellcome Trust
6 · The paper itself

Abstract

backgroundThis paper reports on the outcomes of a proof-of-principle study for the Exposure Therapy Consortium, a global network of researchers and clinicians who work to improve the effectiveness and uptake of exposure therapy. The study aimed to test the feasibility of the consortium's big-team science approach and test the hypothesis that adding post-exposure processing focused on enhancing threat reappraisal would enhance the efficacy of a one-session large-group interoceptive exposure therapy protocol for reducing anxiety sensitivity.

methodsThe study involved a multi-site cluster-randomized controlled trial comparing exposure with post-processing (ENHANCED), exposure without post-processing (STANDARD), and a stress management intervention (CONTROL) in students with elevated anxiety sensitivity. Feasibility was assessed using site performance metrics (e.g., timeline, sample size, missing data). Efficacy was assessed up to 1-month follow-up using the Anxiety Sensitivity Index-3.

resultsDespite challenges posed by unforeseen global crises, a standardized protocol for screening, assessment, and treatment at 12 research sites across four continents was successfully implemented, resulting in a total sample size of 400 with minimal missing data. Challenges in recruitment and adherence to the projected timelines were encountered. Significant reductions in anxiety sensitivity were observed in all conditions. Contrary to hypotheses, group differences were only observed at post-treatment, when ENHANCED and CONTROL outperformed STANDARD but were not significantly different from each other.

conclusionsThis study demonstrates the feasibility of the Exposure Therapy Consortium. Findings raise questions regarding the efficacy of large group exposure interventions and underscore the importance of careful research site selection and an iterative approach to treatment development.

Indexed as

AnxietyAnxiety DisordersImplosive TherapyAdultFeasibility StudiesFemaleHumansMaleProof of Concept StudyTreatment OutcomeYoung AdultAnxiety sensitivityAugmentationBig-team scienceExperimentExposure therapyInteroceptive exposure

Identifiers

PMID39732083
PMCPMC11773450

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.