Evidence map›Paper›PMID 39731725›Full record

ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)2025

White matter hyperintensities and their role in major depressive episodes: a cross-sectional study in adults under 65.

Edouard Baudouin, Emmanuelle Corruble, Pietro Gori, Isabelle Bloch, Laurent Becquemont, Emmanuelle Duron, Romain Colle

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02051413 (Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02051413 phase4completednot on this map

Beta-arrestins and Response to Venlafaxine in Major Depressive Disorder

TypeinterventionalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2014 to 2018Enrolled67ConditionsMajor Depressive Disorder, Major Depressive EpisodeArmsVenlafaxine extended release
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. It is unlikely that major depression severity correlates with white matter lesion volume.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Edouard BaudouinMOODS Team, L'Institut National de la Santéet de la Recherche Medicale, Centre de Recherche en Epidémiologie et Santédes Populations, Facultéde Médecine Paris-Saclay, Université Paris-Saclay, Le Kremlin Bicêtre, France. Department of Geriatrics, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital Paul-Brousse, Villejuif, France.
Emmanuelle CorrubleMOODS Team, L'Institut National de la Santéet de la Recherche Medicale, Centre de Recherche en Epidémiologie et Santédes Populations, Facultéde Médecine Paris-Saclay, Université Paris-Saclay, Le Kremlin Bicêtre, France. Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Mood Center Paris Saclay, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.
Pietro GoriLaboratoire Traitement et Communication de l'Information, Télécom Paris, Institut Polytechnique de Paris, Paris, France.
Isabelle BlochLaboratoire Traitement et Communication de l'Information, Télécom Paris, Institut Polytechnique de Paris, Paris, France. Laboratoire d'Informatique de Paris 6, Centre National de la Recherche Scientifique, Sorbonne Université, Paris, France.
Laurent BecquemontMOODS Team, L'Institut National de la Santéet de la Recherche Medicale, Centre de Recherche en Epidémiologie et Santédes Populations, Facultéde Médecine Paris-Saclay, Université Paris-Saclay, Le Kremlin Bicêtre, France. Clinical Research Center, Assistance Publique-Hôpitaux de Paris, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.
Emmanuelle DuronMOODS Team, L'Institut National de la Santéet de la Recherche Medicale, Centre de Recherche en Epidémiologie et Santédes Populations, Facultéde Médecine Paris-Saclay, Université Paris-Saclay, Le Kremlin Bicêtre, France. Department of Geriatrics, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital Paul-Brousse, Villejuif, France.
Romain ColleMOODS Team, L'Institut National de la Santéet de la Recherche Medicale, Centre de Recherche en Epidémiologie et Santédes Populations, Facultéde Médecine Paris-Saclay, Université Paris-Saclay, Le Kremlin Bicêtre, France. Service Hospitalo-Universitaire de Psychiatrie de Bicêtre, Mood Center Paris Saclay, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, Le Kremlin Bicêtre, France.

Funding

Agence Nationale de la RechercheInstitut National de la Santé Et de la Recherche Médicale
6 · The paper itself

Abstract

objectiveWhite matter hyperintensities (WMH) are associated with major depressive episodes (MDE) in individuals aged 65 and older. WMH are prevalent in adults under 65, yet the association between their volume and MDE in this population remains uncertain. This study aimed to assess the association of WMH volume with MDE and its severity in patients aged < 65.

methodsCross-sectional study (ancillary to clinical trial NCT02051413) of subjects under the age of 65. Overall, 69 patients with MDE and 32 healthy controls (HCs) were included. Severity was assessed with the Hamilton Rating Scale (HRS) and WMH were quantified by two experts. Post-hoc mediation analyses were conducted if associations were found between independent variables and WMH.

resultsMean age was 34.5 (12.4) years. There was no difference in WMH between patients and HCs. Higher WMH volumes were observed in extremely severe MDE (2,170.2 [3,767.9] mm3 vs. 416.6 [594.9] mm3 [r = 0.21; p < 0.05]), which completely mediated the effect of age on severity.

conclusionsIn a sample of adults under 65, this study failed to identify higher WMH volume in patients with MDE compared to HCs. However, WMH may act as a mediator of the association between age and MDE severity. This finding suggests that WMH could contribute to more severe depression in late life.

Indexed as

Major Depressive DisorderWhite MatterAdultAge FactorsCase-Control StudiesCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPsychiatric Status Rating ScalesSeverity of Illness Index

Identifiers

PMID39731725
PMCPMC12815310

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.