Evidence map›Paper›PMID 39731681›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society

Acanthamoeba Infection in a Hematopoietic Cell Transplant Recipient: Challenges in Diagnosis, Management, and Source Identification.

Camellia T Banerjee, Sean Conlan, Anahita Mostaghim, Angela Michelin, Matthew Arduino, Mia Mattioli, Julia C Haston, Sanchita Das, Amir Seyedmousavi, Bickey H Chang and 9 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Camellia T BanerjeeLaboratory of Infectious Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Sean ConlanMicrobial Genomics Section, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Anahita MostaghimHospital Epidemiology Service, Clinical Center, NIH, Bethesda, Maryland, USA.
Angela MichelinHospital Epidemiology Service, Clinical Center, NIH, Bethesda, Maryland, USA.
Matthew ArduinoDivision of Healthcare Quality and Promotion, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, Georgia, USA.
Mia MattioliDivision of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, Georgia, USA.
Julia C HastonDivision of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Atlanta, Georgia, USA.
Sanchita DasMicrobiology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
Amir SeyedmousaviMicrobiology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
Bickey H ChangLaboratory of Immunogenetics, Division of Intramural Research, NIAID, NIH, Bethesda, Maryland, USA.
Elise M O'ConnellClinical Parasitology Unit, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Christopher G KanakryCenter for Immuno-Oncology, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA.
Akbulut DilaraLaboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
Martha QuezadoLaboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USA.
Juan Gea-BanaclocheDivision of Clinical Research, NIAID, NIH, Bethesda, Maryland, USA.
Clay DemingMicrobial Genomics Section, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Julia A SegreMicrobial Genomics Section, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA.
Alison HanHospital Epidemiology Service, Clinical Center, NIH, Bethesda, Maryland, USA.
Jennifer Cuellar-RodriguezTransplant Infectious Diseases, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, Maryland, USA.

Funding

Intramural NIH HHS Z99 AI999999Intramural Research Programs of the National Human Genome Research Institute (NHGRI)National Institute of Allergy and Infectious Diseases (NIAID)NIH Intramural Sequencing Center (NISC)
6 · The paper itself

Abstract

We report a case of Acanthamoeba infection in an HCT recipient with steroid-refractory GVHD. We highlight the multiple challenges that free-living ameba infections present to the clinician, the clinical laboratory, transplant infectious disease for review, hospital epidemiology if nosocomial transmission is considered, and public health officials, as exposure source identification can be a significant challenge. Transplant physicians should include Acanthamoeba infections in their differential diagnosis of a patient with skin, sinus, lung, and/or brain involvement.

Indexed as

AcanthamoebaAmebiasisHematopoietic Stem Cell TransplantationGraft vs Host DiseaseHumansTransplant RecipientsAcanthamoebafree‐living amebaHCTnosocomial

Identifiers

PMID39731681
PMCPMC11827738

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.