ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Cilia-Mimic Locomotion of Magnetic Colloidal Collectives Enhanced by Low-Intensity Ultrasound for Thrombolytic Drug Penetration.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Magnetic Microspheres as Microrobot Bodies: Optimized Chitosan Modification and Gel Dispersion for Controlled Release of Doxorubicin.Micromachines · 2026Article
- Magnetic particle clusters with tunable thrombus penetration for enhanced thrombolysis.Frontiers in bioengineering and biotechnology · 2026Article
- Spatiotemporal-controlled ultrasound-driven Li-PDA@ZnO nanoparticles promote neural stem cell differentiation synergy with biohydrogel repair spinal cord injury.Bioactive materials · 2026Article
- Micro/Nanorobots for Combating Brain Disorders: Challenges, Advances, and Perspectives.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Reconfigurable robust microrobot collectives with large force output enabled by gradient magnetic fields.Science advances · 2025Article
- Cilia-Mimic Locomotion of Magnetic Colloidal Collectives Enhanced by Low-Intensity Ultrasound for Thrombolytic Drug Penetration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Advanced Microrobots Driven by Acoustic and Magnetic Fields for Biomedical Applications.Cyborg and bionic systems (Washington, D.C.) · 2025Review
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Authors and funding
9 authors.
Funding
Abstract
Rapid thrombolysis is very important to reduce complications caused by vascular blockage. A promising approach for improving thrombolysis efficiency is utilizing the permanent magnetically actuated locomotion of nanorobots. However, the thrombolytic drug transportation efficiency is challenged by in-plane rotating locomotion and the insufficient drug penetration limits further improvement of thrombolysis. Inspired by ciliary movement for cargo transportation in human body, in this study, cilia-mimic locomotion of magnetic colloidal collectives is realized under torque-force vortex magnetic field (TFV-MF) by a designed rotating permanent magnet assembly. This cilia-mimic locomotion mode can generate more disturbances to the fluids to improve thrombolytic drug transportation and the increased height and area of colloidal collectives boosted the imaging capability. In addition, low-intensity ultrasound is applied to enhance colloids infiltration by producing the fiber breakage and inducing erythrocyte deformation. In vitro thrombolytic experiments demonstrate that the thrombolysis efficiency increased by 16.2 times compared with that of pure tissue plasminogen activator (tPA) treatments. Furthermore, in vivo rat models of femoral vein thrombosis confirmed that this approach can achieve blood flow recanalization more quickly. The proposed cilia-mimic locomotion of magnetic colloidal collectives combined with low-intensity ultrasound irradiation mode provides a new insight of therapeutic interventions for vascular thrombus by enhancing drug penetration.
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