Evidence map›Paper›PMID 39731308›Full record

ArticleHead & neck2025

The Efficacy of Liquid Biopsy of Total cfDNA for Predicting Systemic Metastasis in Japanese Patients With Oral Squamous Cell Carcinoma.

Masahiro Uchibori, Kazuyoshi Hosomichi, Yasutaka Hoshimoto, Masashi Sasaki, Takayuki Aoki, Atsushi Tajima, Yoshihide Ota, Minoru Kimura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Masahiro UchiboriDepartment of Oral and Maxillofacial Surgery, Tokai University School of Medicine, Isehara, Japan.ORCID 0000-0001-6704-6431
Kazuyoshi HosomichiLaboratory of Computational Genomics, School of Life Science, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Yasutaka HoshimotoDepartment of Oral and Maxillofacial Surgery, Tokai University School of Medicine, Isehara, Japan.
Masashi SasakiDepartment of Oral and Maxillofacial Surgery, Tokai University School of Medicine, Isehara, Japan.
Takayuki AokiDepartment of Oral and Maxillofacial Surgery, Tokai University School of Medicine, Isehara, Japan.
Atsushi TajimaDepartment of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan.
Yoshihide OtaDepartment of Oral and Maxillofacial Surgery, Tokai University School of Medicine, Isehara, Japan.
Minoru KimuraTokai University School of Medicine, Isehara, Japan.

Funding

Grant-in-Aid for Scientific Research from the Japan Society of the Promotion of Science: B,KAKENHI 19H03855Grants-in-Aid for Young Scientists from the Japan Society of the Promotion of Science: KAKENHI 18K17239Grants-in-Aid for Young Scientists from the Japan Society of the Promotion of Science: KAKENHI 22K17022
6 · The paper itself

Abstract

backgroundThe use of liquid biopsy of total cell-free DNA (cfDNA) to identify otherwise undetectable cancers has attracted interest; however, its efficacy remains unknown. We explored whether analysis using total cfDNA is efficacious for Japanese patients with oral squamous cell carcinoma (OSCC).

methodsWe collected total cfDNA from nine patients with OSCC preoperatively, 1 month postoperatively, and every 3 months thereafter to analyze this association. We used a target DNA sequence for genetic mutation analysis of tumor tissues collected from 33 patients, including the aforementioned nine patients.

resultsPatients with good disease control showed negligible changes in preoperative and postoperative total cfDNA concentrations. A rapid increase in total cfDNA concentration was observed in patients who developed systemic metastases. Patients whose tumor tissue DNA showed genetic mutations had the same mutations in preoperative circulating tumor DNA.

conclusionsOur data suggested that analyzing total cfDNA is efficacious for patients with OSCC.

Indexed as

Carcinoma, Squamous CellCell-Free Nucleic AcidsCirculating Tumor DNAMouth NeoplasmsAdultAgedBiomarkers, TumorEast Asian PeopleFemaleHumansJapanLiquid BiopsyMaleMiddle AgedNeoplasm MetastasisBiomarkers, TumorCell-Free Nucleic AcidsCirculating Tumor DNAhead and neck cancerliquid biopsyoral squamous cell carcinomasystemic metastasistotal cfDNA

Identifiers

PMID39731308
PMCPMC12038226

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