Evidence map›Paper›PMID 39731205›Full record

ArticleAging cell2025

Effects of Aging on Glucose and Lipid Metabolism in Mice.

Evan C Lien, Ngoc Vu, Anna M Westermark, Laura V Danai, Allison N Lau, Yetiş Gültekin, Matthew A Kukurugya, Bryson D Bennett, Matthew G Vander Heiden

Abstract read
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Fifteen years of the Diversity Outbred mouse model: a review.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Evan C LienDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, Michigan, USA.
Ngoc VuCalico Life Sciences LLC, South San Francisco, California, USA.
Anna M WestermarkKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Laura V DanaiKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Allison N LauKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Yetiş GültekinKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Matthew A KukurugyaCalico Life Sciences LLC, South San Francisco, California, USA.
Bryson D BennettCalico Life Sciences LLC, South San Francisco, California, USA.
Matthew G Vander HeidenKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID 0000-0002-6702-4192

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Andreea O'Connell · 1985 to 2026
$93.9M
Understanding the role of metabolism in cancerR35CA242379 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI VANDER HEIDEN, MATTHEW G. · 2019 to 2025
$5.8M
Analysis of cancer cell metabolism in diverse environmental conditionsR01CA201276 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VANDER HEIDEN, MATTHEW G., VITKUP, DENNIS · 2016 to 2020
$3.0M
Regulation of glucose metabolism to allow tumor initiation and growthR01CA168653 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI VANDER HEIDEN, MATTHEW G. · 2013 to 2019
$1.9M
Understanding metabolic heterogeneity in pancreatic cancerK99CA234221 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LAU, ALLISON N · 2018 to 2020
$386k
Understanding the effects of dietary interventions on pancreatic ductal adenocarcinoma therapy cancerK99CA255928 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LIEN, EVAN CHEN · 2022 to 2022
$147k
Understanding cell intrinsic and context dependent metabolic adaptations of cancer cellF32CA210421 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI DANAI, LAURA VICTORIA · 2016 to 2017
$88k
NCI NIH HHS F32 CA210421NCI NIH HHS K99 CA234221NCI NIH HHS K99 CA255928NCI NIH HHS P30 CA014051NCI NIH HHS R01 CA168653NCI NIH HHS R01 CA201276NCI NIH HHS R35 CA242379NIH HHS P30CA14051NIH HHS R35CA242379
6 · The paper itself

Abstract

Aging is accompanied by multiple molecular changes that contribute to aging associated pathologies, such as accumulation of cellular damage and mitochondrial dysfunction. Tissue metabolism can also change with age, in part, because mitochondria are central to cellular metabolism. Moreover, the cofactor NAD

Indexed as

AgingGlucoseLipid MetabolismAnimalsMaleMiceMice, Inbred C57BLMuscle, SkeletalNADGlucoseNADagingmetabolic ratemiceNAD

Identifiers

PMID39731205
PMCPMC11984682

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.