ArticleBreast cancer research : BCR2024
Depression risk among breast cancer survivors: a nationwide cohort study in South Korea.
Article in Breast cancer research : BCR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Effect of early integration of supportive care in addition to standard care in patients with breast cancer: A randomised controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- A comprehensive evaluation of the health benefits of forest therapy for cancer survivors.Environmental health and preventive medicine · 2026Trial
- Global trends in psychosexual and emotional health challenges among breast cancer survivors (1999-2024): Implications for public health and survivorship care.Public health in practice (Oxford, England) · 2026Article
- Machine learning-based risk classification of depressive symptoms among patients with hearing loss: evidence from the Health and Retirement Study (HRS).Comprehensive psychoneuroendocrinology · 2026Article
- Transcutaneous vagus nerve stimulation in breast cancer: a neuroimmune model to improve quality of life.Frontiers in oncology · 2026Article
- Network analysis of quality of life among young and middle-aged Korean cancer survivors.Asia-Pacific journal of oncology nursing · 2025Article
- Emotional Functioning as a Dimension of Quality of Life in Breast Cancer Survivors: A Systematic Review and Meta-Analysis.Cancers · 2025Review
- Advances in radiotherapy in the treatment of esophageal cancer.World journal of clinical oncology · 2025Article
- Depression risk among breast cancer survivors: a nationwide cohort study in South Korea.Breast cancer research : BCR · 2024Article
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8 authors.
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Abstract
backgroundDepression among breast cancer survivors is a significant concern affecting their long-term survivorship and quality of life. This study investigates the incidence of depression among breast cancer survivors and identifies associated risk factors.
methodsThis retrospective cohort study used data from the Korean National Health Insurance Service database and included 59,340 breast cancer patients without a history of depression who underwent surgery between January 1, 2010, and December 31, 2016. They were individually matched 1:2 by age with a general population without cancer (n = 99,834). The mean follow-up period was 6.4 ± 2.6 years. Sub-distribution hazard ratios (sHRs) and 95% confidence intervals (CIs) were calculated considering death as a competing risk and adjusting for sociodemographic factors and comorbidities.
resultsBreast cancer survivors with a mean (standard deviation) age of 51.5 (9.2) years had a 39% increased risk of depression compared to non-cancer controls (sHR 1.39, 95% CI 1.36-1.42). During the first year post-diagnosis, breast cancer survivors across all ages exhibited a significantly elevated risk of depression, with a sHR of 3.23 (95% CI 3.08-3.37). Notably, younger survivors had a sHR of 4.51 (95% CI 4.19-4.85), and older survivors had a sHR of 2.56 (95% CI 2.42-2.71). One year post-surgery, younger survivors (age ≤ 50 years) showed a 1.16-fold increase in depression risk (sHR 1.16, 95% CI 1.11-1.20), while older survivors (age > 50 years) showed no significant change in risk, which decreased over time. Use of anthracycline, taxane, or endocrine therapy was associated with an increased depression risk (sHR 1.17, 95% CI 1.13-1.22; sHR 1.12, 95% CI 1.07-1.16; and sHR 1.27, 95% CI 1.14-1.41, respectively), with endocrine therapy showing a 41% increased depression risk in older survivors (sHR 1.41, 95% CI 1.23-1.61).
conclusionThis study demonstrates a significant association between breast cancer and depression, with a particularly heightened risk in younger survivors within the first year post-diagnosis. Special attention is needed to meticulously screen for depressive symptoms during the early follow-up years for breast cancer survivors who are premenopausal or have undergone chemotherapy and endocrine therapy.
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