ArticleCritical care (London, England)2024
Definitions, epidemiology, and outcomes of persistent/chronic critical illness: a scoping review for translation to clinical practice.
Article in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Abnormal carnitine concentrations in critical illness associated with compromised outcome.Critical care (London, England) · 2026Trial
- Long-term survival of patients with persistent critical illness in Australia and New Zealand; a retrospective registry-based cohort study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026Article
- Temporal Discordance of the Inflammation, Catabolism and Immunosuppression Triad in Chronic Critical Illness.Medicina (Kaunas, Lithuania) · 2026Article
- Effectiveness of a standardized weaning protocol in tracheostomized patients with prolonged mechanical ventilation: a prospective single-arm interventional trial.Journal of intensive care · 2026Article
- Day-7 lactate-to-albumin ratio as a prognostic marker in sepsis patients requiring prolonged mechanical ventilation: a multicenter retrospective landmark analysis of the Korean Sepsis Alliance registry.Journal of thoracic disease · 2026Article
- Development and Validation of a Nomogram for Mortality Prediction in Septic Patients with Prolonged or Chronic Critical Illness.Diagnostics (Basel, Switzerland) · 2026Article
- Early Prediction and Prognostic Value of Chronic Critical Illness and Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Patients with Severe Acute Pancreatitis: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- Development and external validation of a machine learning model for predicting chronic critical illness in ICU patients with acute pancreatitis.BMC medical informatics and decision making · 2026Article
- A Nomogram for Early Prediction of Inflammation, Catabolism, and Immunosuppression Syndrome in Critically Ill Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Precision Oxygen Therapy in the Intensive Care Unit: Matching Oxygen Exposure to Patient Phenotypes.Journal of personalized medicine · 2026Article
- Guidelines for the construction and management of critical care medicine in China (2025 Edition).Journal of intensive medicine · 2026Article
- Machine Learning Model for Sepsis Prediction in Prolonged and Chronic Critical Illness: Development and Validation Using Retrospective Real-World ICU Data.Journal of clinical medicine · 2026Article
- Family-led post-ICU discharge intervention for tracheostomized patients in India: Feasibility and formative impact evaluation.PloS one · 2026Article
- Factors Influencing Functional Recovery in People After Chronic Critical Illness During Early Neurological Rehabilitation.Journal of multidisciplinary healthcare · 2026Article
- The ICS triad in critical illness: a time-dependent pathological driver of mortality and organ dysfunction.Frontiers in medicine · 2026Article
- A Reflection on Current Definitions of Critical Care and Critical Illness-A Narrative Review of the Literature.Nursing in critical care · 2026Review
- APACHE II and NUTRIC Scores for Mortality Prediction in Chronic Critical Illness: A "Right-Side" Prognostic Modeling Approach.Diagnostics (Basel, Switzerland) · 2025Article
- What's in a Name? The Ongoing Tangle of Chronic Critical Illness, Persistent Critical Illness, and Prolonged Acute Mechanical Ventilation.Annals of the American Thoracic Society · 2025Article
- Non-pharmacological post-intensive care interventions to improve patient outcome following critical illness: a scoping review.Critical care (London, England) · 2025Review
- An enhanced nutrition support system is associated with greater adequacy of enteral nutrition in long-term ICU patients: a retrospective cohort study.BMC nutrition · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMedical advances in intensive care units (ICUs) have resulted in the emergence of a new patient population-those who survive the initial acute phase of critical illness, but require prolonged ICU stays and develop chronic critical symptoms. This condition, often termed Persistent Critical Illness (PerCI) or Chronic Critical Illness (CCI), remains poorly understood and inconsistently reported across studies, resulting in a lack of clinical practice use. This scoping review aims to systematically review and synthesize the existing literature on PerCI/CCI, with a focus on definitions, epidemiology, and outcomes for its translation to clinical practice.
methodsA scoping review was conducted using MEDLINE and Scopus, adhering to the PRISMA-ScR guidelines. Peer-reviewed original research articles published until May 31, 2024 that described adult PerCI/CCI in their definitions of patient populations, covariates, and outcomes were included. Data on definitions, epidemiology, and outcomes were extracted by a data charting process from eligible studies and synthesized.
resultsNinety-nine studies met the inclusion criteria. Of these studies, 64 used the term CCI, 18 used PerCI, and 17 used other terms. CCI definitions showed greater variability, while PerCI definitions remained relatively consistent, with an ICU stay ≥ 14 days for CCI and ≥ 10 days for PerCI being the most common. A meta-analysis of the prevalence of PerCI/CCI among the denominators of "all ICU patients", "sepsis", "trauma", and "COVID-19" showed 11% (95% confidence interval 10-12%), 28% (22-34%), 24% (15-33%), and 35% (20-50%), respectively. A meta-analysis of in-hospital mortality was 27% (26-29%) and that of one-year mortality was 45% (32-58%). Meta-analyses of the prevalence of CCI and PerCI showed 17% (16-18%) and 18% (16-20%), respectively, and those for in-hospital mortality were 28% (26-30%) and 26% (24-29%), respectively. Functional outcomes were generally poor, with many survivors requiring long-term care.
conclusionsThis scoping review synthesized many studies on PerCI/CCI, highlighting the serious impact of PerCI/CCI on patients' long-term outcomes. The results obtained underscore the need for consistent terminology with high-quality research for PerCI/CCI. The results obtained provide important information to be used in discussions with patients and families regarding prognosis and care options.
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