SynthesisWorld journal of surgical oncology2024
Non-surgery strategy versus hepatectomy in hepatocellular carcinoma patients with complete response after conversion therapy: a meta-analysis.
Synthesis in World journal of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploring disparities in adherence to colorectal cancer clinical practice guidelines and associated survival outcomes: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Pooled it
- Safety and efficacy of salvage surgery for unresectable hepatocellular carcinoma after conversion with triple therapy: a systematic review and meta-analysis of data from Chinese patients.World journal of surgical oncology · 2025Pooled it
- Advances in the Therapeutic Landscape of Hepatocellular Carcinoma: Current Strategies and Future Perspectives.Cancers · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is ongoing debate surrounding the optimal therapeutic strategy for hepatocellular carcinoma (HCC) patients achieving complete response (CR) after conversion therapy. This meta-analysis compares the prognostic outcomes of non-surgery strategies with hepatectomy.
methodsThe systematic searches were conducted up to April 11, 2024, across PubMed, Embase, Web of Science, and the Cochrane Library, analyzing progression-free survival (PFS) and overall survival (OS). Subgroup analyses were conducted based on whether patients achieved a clinical CR or a radiologic CR, as well as the regimen of non-surgery strategy employed.
resultsSix studies with 481 patients were identified. Non-surgery strategy was linked to significantly worse PFS compared to hepatectomy (hazard ratio [HR] = 2.15; 95% confidence interval [CI], 1.60 to 2.90). However, there was not a notable difference in OS between the two groups (HR = 1.35; 95% CI, 0.93 to 1.96). Subgroup analysis showed that for patients with clinical CR, there were no notable differences in both PFS and OS. Conversely, patients with radiologic CR experienced significantly worse PFS and OS when treated with non-surgery strategy.
conclusionsNon-surgery strategy might provide comparable outcomes to hepatectomy for HCC patients with clinical CR, as opposed to those with radiologic CR. Further research is needed to confirm these results.
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