ArticleAnnals of surgical oncology2025
Association Between Treatment-Related Adverse Event Trajectory and Prognosis in Esophageal Cancer Receiving Neoadjuvant Immunochemotherapy.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Development of a predictive model for pathological complete response following neoadjuvant immunotherapy and chemotherapy in locally advanced resectable esophageal squamous cell carcinoma.World journal of surgical oncology · 2026Article
- Influence of early temperature trajectories on clinical outcomes in traumatic brain injury: a multicenter validation study using machine learning.European journal of medical research · 2025Article
- Pretreatment immune-inflammatory prognostic score in predicting clinical outcomes in esophageal squamous cell carcinoma receiving neoadjuvant immunochemotherapy.Frontiers in immunology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundImmunochemotherapy is inevitably accompanied with treatment-related adverse events (TRAEs). However, TRAEs are typically assessed at a single time point, overlooking the complexity of TRAE trajectories over time. This study aimed to characterize TRAE trajectories during multi-cycle neoadjuvant immunochemotherapy (nICT) and identify potential prognostic factors for patients with esophageal squamous cell carcinoma (ESCC).
methodsThis prospective cohort study enrolled locally advanced ESCC patients treated with nICT between July 2020 and August 2022. The study recorded and graded TRAEs according to common terminology criteria for adverse events (CTCAE) v5.0. Latent-class mixed-modeling (LCMM) was used to identify the TRAE trajectories. Prognosis and tumor response of different TRAE trajectories were further analyzed.
resultsThe study finally enrolled 75 eligible patients (mean age, 62.4 years; 77.3% male). The major TRAEs with high incidence were fatigue (90.7%), alopecia (74.7%), pruritus (60.0%), nausea (49.3%), vomiting (41.3%), and pain (33.3%). Two- and three-cluster trajectory models provided the best fit for TRAEs. Most TRAEs showed improvement over time except for the subgroups of fatigue and alopecia, which tended to worsen. Furthermore, the patients with a severe gastrointestinal TRAE trajectory had poorer overall survival than those with a mild gastrointestinal TRAE trajectory (hazard ratio
conclusionsFor patients with locally advanced ESCC, most TRAEs such as pruritus, nausea, vomiting, and pain improved over time, whereas fatigue and alopecia tended to worsen in multi-cycle nICT. A mild gastrointestinal TRAE trajectory was associated with better survival.
Indexed as
Identifiers
39730967What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.