ReviewNature biomedical engineering2025
Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation.
Review in Nature biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.Nature medicine · 2026Article
- Integrated Ultrasonic Platform for Bioelectronic Control through Biological Barriers Based on Metasurface.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation.Nature biomedical engineering · 2026Article
- Multitarget brain implants enable generalized decoding of Parkinson's disease symptoms from chronic home recordings.Research square · 2026Article
- AI-based discovery of functional boundaries in the human brain from intraoperative electrophysiology.medRxiv : the preprint server for health sciences · 2026Article
- Understanding the Effects of Conductive Polymer Electrode Coating on Recorded Neural Signals.Advanced healthcare materials · 2026Article
- Translational prospectives for deep brain stimulation and low-intensity focused ultrasound neuromodulation: IFCN Handbook chapter.Clinical neurophysiology practice · 2026Review
- Electrophysiological signatures predict the therapeutic window of deep brain stimulation electrode contacts.NPJ digital medicine · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Deep brain stimulation (DBS), a proven treatment for movement disorders, also holds promise for the treatment of psychiatric and cognitive conditions. However, for DBS to be clinically effective, it may require DBS technology that can alter or trigger stimulation in response to changes in biomarkers sensed from the patient's brain. A growing body of evidence suggests that such adaptive DBS is feasible, it might achieve clinical effects that are not possible with standard continuous DBS and that some of the best biomarkers are signals from the cerebral cortex. Yet capturing those markers requires the placement of cortex-optimized electrodes in addition to standard electrodes for DBS. In this Perspective we argue that the need for cortical biomarkers in adaptive DBS and the unfortunate convergence of regulatory and financial factors underpinning the unavailability of cortical electrodes for chronic uses threatens to slow down or stall research on adaptive DBS and propose public-private partnerships as a potential solution to such a critical technological gap.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.