Evidence map›Paper›PMID 39730872›Full record

ArticleMikrochimica acta2024

A novel electrochemical immunosensor for the ultrasensitive detection of vascular endothelial growth factor based on MB@Cu-MOFs/MWCNTs composite.

Junjie Liu, Shengxi Wu, Lu Zhang, Mingjun Zhang, Haotian Wu, Miwan Shi, Yuan Weng, Wenqiao Ye, Kui Gu

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junjie LiuSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Shengxi WuSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China. sxwu2004@cqut.edu.cn.
Lu ZhangSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Mingjun ZhangChongqing Jiulongpo District People's Hospital, Chongqing, 400050, China.
Haotian WuDepartment of Physics and Energy, Chongqing University of Technology, Chongqing, 400054, China.
Miwan ShiSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Yuan WengSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Wenqiao YeSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China.
Kui GuSchool of Pharmacy and Bioengineering, Chongqing University of Technology, Chongqing, 400054, China. gukui0404@cqut.edu.cn.

Funding

Graduate Student Innovation Program of Chongqing University of Technology gzlcx2023338Natural Science Foundation of Chongqing CSTB2024NSCQ-MSX0139Science and Technology Project of Chongqing Education Commission (KJZD-K201901101Scientific Research Foundation of Chongqing University of Technology 2024ZDZ004
6 · The paper itself

Abstract

A novel proposal is introduced with an unlabeled electrochemical immunosensor for the detection of tumor broad-spectrum biomarker vascular endothelial growth factor (VEGF165) Copper-based metal organic frameworks (Cu MOFs)-carbon nanotubes (MWCNTs) were employed as its substrates, functionalized with methylene blue (MB) for signal enhancement. Cu-MOFs-MWCNTs nanocomposites were synthesized successfully via a solvothermal method and were then deposited on the surface of a glassy carbon electrode (GCE), with the addition of methylene blue to amplify the signal. Due to the expansive specific surface area provided by the carbon nanotubes and the amino groups facilitated by the metal-organic framework nanomaterials, the anti-VEGF165 monoclonal antibody was immobilized on the electrochemical immunosensor through covalent bonding, which could bind specifically to VEGF165, thereby causing a detectable change in the current. The developed immunosensor exhibited a linear detection range for VEGF165 spanning from 1 to 100,000 pg/ml, with the R

Indexed as

Antibodies, ImmobilizedBiosensing TechniquesCopperElectrochemical TechniquesLimit of DetectionMetal-Organic FrameworksNanotubes, CarbonVascular Endothelial Growth Factor AElectrodesHumansImmunoassayMethylene BlueNanocompositesReproducibility of ResultsAntibodies, ImmobilizedCopperMetal-Organic FrameworksMethylene BlueNanotubes, CarbonVascular Endothelial Growth Factor AVEGFA protein, humanCu-MOFs-MWCNTsDifferential pulse voltammetryElectrochemical immunosensorModified glassy carbon electrodeTumor markersVascular endothelial growth factor (VEGF165)

Identifiers

PMID39730872

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.