Evidence map›Paper›PMID 39730704›Full record

ArticleScientific reports2024

Neratinib enhances the efficacy of CDK4/6 inhibitor plus endocrine therapy in HR

Liushan Chen, Lingling Ye, Yuqi Liang, Wei Luo, Qian Zuo, Ping Huang, Yuyu Hu, Yan Dai, Yingchao Wu, Qianqian Guo and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liushan Chen *Chinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China.
Lingling Ye *Chinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China.
Yuqi Liang *Chinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China.
Wei LuoChinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China.
Qian ZuoChinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China.
Ping HuangChinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China.
Yuyu HuChinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China.
Yan DaiChinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China.
Yingchao WuChinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China. yc1996@stu2020.jnu.edu.cn.
Qianqian GuoChinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China. guoqianqian@gzucm.edu.cn.
Qianjun ChenChinese Medicine Guangdong Laboratory, Hengqin, 519031, Guangdong, China. cqj55@163.com.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2022A1515110859National Natural Science Foundation of China 82274513Project supported by the Incubation Program for the Science and Technology Development of Chinese Medicine Guangdong Laboratory HQL2024PZ023Science and Technology Innovation Medical Development Foundation of Beijing KC2021-ZZ-0010-9Science and Technology Innovation Medical Development Foundation of Beijing KC2022-ZZ-0091-1
6 · The paper itself

Abstract

HR

Indexed as

Breast NeoplasmsCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6Erb-b2 Receptor Tyrosine KinasesMicroRNAsQuinolinesAnimalsAntineoplastic Combined Chemotherapy ProtocolsCell Line, TumorDrug SynergismFemaleGene Expression Regulation, NeoplasticHumansMiceProtein Kinase InhibitorsReceptors, EstrogenCDK4 protein, humanCDK6 protein, humanCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 6ERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesMicroRNAsneratinibProtein Kinase InhibitorsQuinolinesReceptors, EstrogenReceptors, ProgesteroneCDK4/6 inhibitorEndocrine therapyHER2 mRNA stabilityHR+/HER2-lowHsa-miR-23a-5pNeratinib

Identifiers

PMID39730704
PMCPMC11680982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.