Evidence map›Paper›PMID 39730670›Full record

ArticleScientific reports2024

Association between sensitivity to thyroid hormone indices and type 2 diabetic microvascular complications in euthyroid patients.

Junping Zhang, Zhanpeng Luo, Jie Zhang, Ruohao Zhang, Xinnan Liu, Jinying Wang, Shasha He, Jiao Wang, Dandan Chen, Cuiyun Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Junping Zhang *Department of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Zhanpeng Luo *Department of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jie Zhang *Department of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Ruohao ZhangThe First Clinical Medical College, Jiangxi Medical College of Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Xinnan LiuThe First Clinical Medical College, Jiangxi Medical College of Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Jinying WangDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Shasha HeDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jiao WangDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Dandan ChenDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Cuiyun ChenDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jiancheng WangDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China.
Shen ChenDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Shensen0709@163.com.
Jixiong XuDepartment of Endocrine and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. Jixiong.Xu@ncu.edu.cn.

Funding

Jiangxi Provincial Natural Science Foundation 20224ACB206010Jiangxi Provincial Science and Technology Innovation Base Construction - Clinical Medical Research Center 20221ZDG02011Jiangxi Provincial Science and Technology Innovation Base Plan - Provincial Clinical Medical Research Center 2020BCG74001
6 · The paper itself

Abstract

The correlation between thyroid hormone (TH) sensitivity and microvascular complications of type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to explore the association between TH sensitivity and the risk of diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic neuropathy (DNP) in euthyroid T2DM patients. This study included a total of 946 hospitalized T2DM patients and calculated their sensitivity to the TH index, and each patient completed screenings for DKD, DR, and DNP. Multivariate logistic regression, generalized additive modeling, and subgroup analysis were used to assess the association between TH index sensitivity and the risks of DKD, DR, and DNP. After adjusting for confounding factors, a significant linear correlation was observed between the sensitivity of the thyroid feedback quartile index 3 (TFQI3) and DKD risk. However, the sensitivities of thyroid-stimulating hormone index (TSHI), thyrotropin thyroxine resistance index (TT4RI) and partial thyroid feedback quartile index (PTFQI) exhibited nonlinear correlations with the risk of developing DKD. The effect sizes to the left of the inflection point for TSHI, TT4RI and PTFQI were (odd ratio [OR] = 0.53, 95% confidence interval [CI]: 0.288-0.977), (OR = 0.863, 95%Cl: 0.751-0.992) and (OR = 0.007, 95%Cl: 0-0.724), respectively. However, there was no significant correlation between TH index sensitivity and DR/DNP risk. This study provides valuable insights into the relationship between TH sensitivity and the risks of DKD, DR, and DNP, with substantial clinical implications for individual prediction among T2DM patients.

Indexed as

Diabetes Mellitus, Type 2Thyroid HormonesAgedDiabetic NephropathiesDiabetic NeuropathiesDiabetic RetinopathyFemaleHumansMaleMiddle AgedRisk FactorsThyroid GlandThyrotropinThyroxineThyroid HormonesThyrotropinThyroxineDiabetic kidney diseaseDiabetic neuropathyDiabetic retinopathyThyroid hormone sensitivityType 2 diabetic microvascular complications

Identifiers

PMID39730670
PMCPMC11681052

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.