ArticleScientific reports2024
Structural changes in the retina and choroid in patients with different degrees of myopia.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Effect of full spectrum indoor lighting on myopia progression in school-aged children: a prospective cohort study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Eight-Year Post-Trial Outcomes of a Two-Year Clinical Trial of DIMS Spectacle Lenses.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Shared Genetic Architecture and Multidimensional Modifiable Correlates between Myopia and Retinal-Optic Nerve Diseases.Ophthalmology science · 2026Article
- Myopia as a Global Public Health Challenge a Narrative Review.Life (Basel, Switzerland) · 2026Review
- Long-term axial elongation in myopic children wearing DIMS spectacle lenses: an 8-to-10-year observational study.BMJ open ophthalmology · 2026Observational
- Differential regulation of myopia progression by ON and OFF stimulation in guinea pigs.Eye and vision (London, England) · 2026Article
- Diagnostic challenges in high myopia: identification of sight-threatening complications and the role of artificial intelligence.Frontiers in ophthalmology · 2025Review
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Authors and funding
6 authors.
Funding
Abstract
To observe the structural changes of retina and choroid in patients with different degrees of myopia. We recruited 219 subjects with different degrees of myopia for best corrected visual acuity, computer refraction, intraocular pressure, axial length (AL), optical coherence tomography (OCT) imaging, and other examinations. Central macular retinal thickness (CRT), subfoveal choroidal thickness (SFCT), nasal retinal thickness (NRT), temporal retinal thickness (TRT), nasal choroidal thickness (NCT) and temporal choroidal thickness (TCT) were measured by optical coherence tomography. ImageJ software was used to measure the retinal area and choroidal area (CA), and Niblack was used to binarize all OCT images to measure the choroidal vessel area (CVA) and choroidal matrix area (CMA). We found that CRT, SFCT, NRT, TRT, NCT, TCT, CA, CVA, and CMA were significantly reduced in the pathological myopia (PM) group. AL was negatively correlated with NRT, SFCT, CMA, CVA and choroidal stromal index. There was a significant positive correlation between AL and choroidal vascular index. The choroidal vascular index in the PM group was significantly increased compared with the other groups. We established a univariate receiver operating curve to analyze the diagnostic value of all parameters for PM. Spherical equivalent, AL, SFCT, TCT, NCT, CA, CVA, and CMA had high diagnostic value for PM, among which CMA had the highest accuracy. There are changes in choroidal structure in adults with different degrees of myopia. Choroidal thickness, CVA and CMA decrease significantly with the increase of myopia, and are correlated with AL. The decrease of CMA has higher diagnostic value in myopia.
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