Evidence map›Paper›PMID 39730435›Full record

ArticleScientific reports2024

Genomic analysis of DS-1-like human rotavirus A strains uncovers genetic relatedness of NSP4 gene with animal strains in Manhiça District, Southern Mozambique.

Filomena Manjate, Eva D João, Peter Mwangi, Percina Chirinda, Milton Mogotsi, Marcelino Garrine, Augusto Messa, Delfino Vubil, Nélio Nobela, Karen Kotloff and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Filomena ManjateCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Eva D JoãoCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Peter MwangiNext Generation Sequencing Unit, Division of Virology, Faculty of Health Sciences, University of the Free State, Bloemfontein, 9300, South Africa.
Percina ChirindaCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Milton MogotsiNext Generation Sequencing Unit, Division of Virology, Faculty of Health Sciences, University of the Free State, Bloemfontein, 9300, South Africa.
Marcelino GarrineCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Augusto MessaCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Delfino VubilCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Nélio NobelaCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Karen KotloffCenter for Vaccine Development, School of Medicine, University of Maryland, Baltimore, MD, 21201, USA.
James P NataroDepartment of Paediatrics, University of Virginia School of Medicine, Charlottesville, VA, 22903, USA.
Tacilta NhampossaCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Sozinho AcácioCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Goitom WeldegebrielAfrican Rotavirus Surveillance Network, Immunization, Vaccines and Development Program, World Health Organization (WHO), Regional Office for Africa, P.O. Box 2465, Brazzaville, Republic of Congo.
Jacqueline E TateCenters for Disease Control and Prevention (CDC), Atlanta, GA, 30333, USA.
Umesh ParasharCenters for Disease Control and Prevention (CDC), Atlanta, GA, 30333, USA.
Jason M MwendaAfrican Rotavirus Surveillance Network, Immunization, Vaccines and Development Program, World Health Organization (WHO), Regional Office for Africa, P.O. Box 2465, Brazzaville, Republic of Congo.
Pedro L AlonsoCentro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Celso CunhaGlobal Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, Rua da Junqueira 100, 1349-008, Lisboa, Portugal.
Martin Nyaga *Next Generation Sequencing Unit, Division of Virology, Faculty of Health Sciences, University of the Free State, Bloemfontein, 9300, South Africa.
Inácio Mandomando *Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique. inacio.mandomando@manhica.net.

Funding

Fundo Nacional de Investigação (FNI), Moçambique 245-INVGates Foundation OPP1126780The Bill & Melinda Gates Foundation (OPP1033572) MOA #..870-15 SCThe United States Agency for International Development (USAID) AID-656-F-16-00002World Health Organization 001
6 · The paper itself

Abstract

Post rotavirus vaccine introduction in Mozambique (September 2015), we documented a decline in rotavirus-associated diarrhoea and genotypes changes in our diarrhoeal surveillance spanning 2008-2021. This study aimed to perform whole-genome sequencing of rotavirus strains from 2009 to 2012 (pre-vaccine) and 2017-2018 (post-vaccine). Rotavirus strains previously detected by conventional PCR as G2P[4], G2P[6], G3P[4], G8P[4], G8P[6], and G9P[6] from children with moderate-to-severe and less-severe diarrhoea and without diarrhoea (healthy community controls) were sequenced using Illumina MiSeq

Indexed as

DiarrheaGenome, ViralGenotypePhylogenyRotavirusRotavirus InfectionsToxins, BiologicalViral Nonstructural ProteinsAnimalsCattleChild, PreschoolHumansInfantMozambiqueRotavirus VaccinesWhole Genome SequencingNS28 protein, rotavirusRotavirus VaccinesToxins, BiologicalViral Nonstructural ProteinsChildren with diarrhoeaChildren without diarrhoeaManhiça districtMozambiqueRotavirus group AWhole genome sequencing

Identifiers

PMID39730435
PMCPMC11680989

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.