ArticleScientific reports2024
Association between volatile organic compounds exposure and infertility risk among American women aged 18-45 years from NHANES 2013-2020.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Mapping the Global Evidence on Environmental and Climatic Factors Linked to Human Fertility-Related Outcomes: Protocol for a Scoping Review.JMIR research protocols · 2026Article
- Recent advances in sex-specific reproductive microphysiological systems for the systematic evaluation of assisted reproductive technology.Materials today. Bio · 2026Review
- Infertility Risk and Employment History Among US Women: Findings From National Health and Nutrition Examination Survey 2013-2014.American journal of industrial medicine · 2026Article
- Exposomics as a discovery engine for emerging contaminants and hidden biological risks.Emerging contaminants · 2026Article
- Exploring the nexus between particulate matter and infertility: Multiple mechanistic insights and potential control strategies.iScience · 2026Review
- Cigarette use, secondhand smoke exposure and age-related infertility among US women: A cross-sectional NHANES study.Tobacco prevention & cessation · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The risk of infertility is progressively escalating over the years, and it has been established that exposure to environmental pollutants is closely linked to infertility. As a prevalent environmental pollutant in daily life, there is still a lack of substantial evidence on the association between volatile organic compounds (VOCs) exposure and infertility risk. This study aimed to examine the association between VOCs exposure and the risk of female infertility in the United States. Participant data sets from three cycles (2013-2020) were collected and downloaded from the National Health and Nutrition Examination Survey (NHANES), including demographics, examination, laboratory and questionnaire data. The baseline characteristics of the included population were evaluated, and the weighted quartile logistic regression was used to analyze the association between the urinary metabolites of VOCs (mVOCs) levels and the risk of infertility. Further exploration of the relationship between mVOCs and infertility was conducted by using 35 and 25 as the cut-off points for age and BMI subgroup analyses, respectively. Restricted cubic spline (RCS) was employed to elucidate the nonlinear relationship between mVOCs and infertility risk. Additionally, the Bayesian kernel machine regression (BKMR) model with 20,000 iterations was applied to elucidate the link between mVOCs and the risk of infertility when exposed to mixed or individual mVOCs. A total of 1082 women aged 18 to 45 years were included in this study, with 133 in the infertility group and 949 in the control group. The analysis of baseline characteristics suggested that urinary 34MHA, AMCC and DHBMA levels were significantly higher in the infertility group compared to the control group (p < 0.05). Quartile logistic regression analysis indicated that AAMA (Q3), AMCC (Q4), CYMA (Q3) and HPMMA (Q3) were positively associated with infertility risk in all models (p < 0.05). Subgroup analysis revealed different risk factors for infertility among various subgroups, with CYMA consistently showing a positive correlation with infertility risk in two age subgroups (p < 0.05). Furthermore, the association between mVOCs and infertility was observed only in the subgroup with BMI ≥ 25 kg/m
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