ArticleThe Journal of clinical investigation1985
A monokine stimulates production of human erythroid burst-promoting activity by endothelial cells in vitro.
Article in The Journal of clinical investigation, 1985. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 47 citations in OpenAlex.
- Specific inhibition of interleukin 3 bioactivity by a monoclonal antibody reactive with hematopoietic progenitor cells.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Sequential events in the pathogenesis of streptococcal cell wall-induced arthritis and their modulation by bis(5-amidino-2-benzimidazolyl)methane (BABIM).The American journal of pathology · 1990Article
- Interleukin 1-dependent paracrine granulopoiesis in chronic granulocytic leukemia of the juvenile type.The Journal of clinical investigation · 1988Article
- Acetylated lipoproteins impair erythroid growth factor release from endothelial cells.The Journal of clinical investigation · 1988Article
- Hematopoietic growth factors.The Journal of clinical investigation · 1987Article
- Interleukin 1 induces cultured human endothelial cell production of granulocyte-macrophage colony-stimulating factor.The Journal of clinical investigation · 1987Article
- Interleukin 1 stimulates granulocyte macrophage colony-stimulating activity release by vascular endothelial cells.The Journal of clinical investigation · 1986Article
- Tumor necrosis factor type alpha stimulates human endothelial cells to produce granulocyte/macrophage colony-stimulating factor.Proceedings of the National Academy of Sciences of the United States of America · 1986Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Conditioned media were prepared from human peripheral blood monocytes and human umbilical vein endothelial cells. These media were assayed for erythroid burst-promoting activity (BPA) using human peripheral blood monocyte-depleted mononuclear cells as targets and assessing the stimulatory effect of the conditioned media on growth of early erythroid progenitor cells. Both monocytes and endothelial cells produced modest amounts of detectable BPA. Addition of varying concentrations of media conditioned by monocytes to plateau concentrations (5-10%) of media conditioned by endothelial cells had no additive effect. Endothelial cells incubated in the presence of 50% monocyte-conditioned medium produced 2.5- to 6.6-fold more BPA than did endothelial cells incubated only in control tissue culture medium. In contrast, endothelial cell conditioned medium did not stimulate increased BPA production by monocytes. Neither neutrophil- nor marrow fibroblastoid cell-conditioned medium stimulated BPA production by endothelial cells. Therefore, both monocytes and endothelial cells produce BPA. Moreover, monocytes produce a monokine that, in turn, stimulates the production of BPA by endothelial cells. Inasmuch as a monokine also has been shown to stimulate production of granulocyte-macrophage colony-stimulating activity, we propose that monocytes play a critical role in regulating the production of humoral regulators of the very early stages of hemopoietic cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.