Evidence map›Paper›PMID 39730156›Full record

ArticleAJNR. American journal of neuroradiology2025

Cognitive Control Network and Language Reorganization in Patients with Brain Tumors.

Luca Pasquini, Antonio Napolitano, Leonardo Spitoni, Maurizio Schmid, Francesco Dellepiane, Mehrnaz Jenabi, Kyung Peck, Andrei Holodny

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luca PasquiniFrom the Neuroradiology Service (L.P.), Radiology Department, Yale New Haven Hospital, Yale Medical School, New Haven, Connecticut lucapasquini3@gmail.com.ORCID 0000-0003-1679-6958
Antonio NapolitanoMedical Physics Department (A.N., L.S.), Bambino Gesù Children's Hospital, Rome, Italy.ORCID 0000-0003-3258-6846
Leonardo SpitoniMedical Physics Department (A.N., L.S.), Bambino Gesù Children's Hospital, Rome, Italy.
Maurizio SchmidDepartment of Engineering (M.S.), University Roma Tre, Rome, Italy.
Francesco DellepianeNeuroradiology Service (F.D.), Radiology Department, Bambino Gesù Children's Hospital, Rome, Italy.
Mehrnaz JenabiNeuroradiology Service (L.P., M.J., A.H.), Radiology Department, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-2456-0737
Kyung PeckDepartment of Medical Physics (K.P.), Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-9841-3078
Andrei HolodnyNeuroradiology Service (L.P., M.J., A.H.), Radiology Department, Memorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0002-1159-2705

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Supplement: Network Methods for Brain Imaging with TumorsR01EB022720 · NIBIB · CITY COLLEGE OF NEW YORK · PI HOLODNY, ANDREI I, MAKSE, HERNAN · 2016 to 2018
$1.3M
Identification of Essential Areas of the Brain in Pre-Operative Brain Tumor Patients Using BOLD fMRI and Independent Physiological ParametersR21CA220144 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI HOLODNY, ANDREI I, PECK, KYUNG · 2017 to 2019
$427k
NCI NIH HHS P30 CA008748NCI NIH HHS R21 CA220144NIBIB NIH HHS R01 EB022720
6 · The paper itself

Abstract

background and purposeThe interaction between language and other cognitive networks in patients harboring brain tumors is poorly understood. We studied the modification of the cognitive control network (CCN) induced by brain tumors and its participation in language reorganization. We hypothesized that patients with brain tumors and reorganized language would show a modification of the CCN compared with patients who remain left dominant. MATERIALS AND

methodsPatients were selected with the criteria: newly diagnosed, pathologically-confirmed left-hemispheric tumor; single lesions; right-handedness; task-based and resting-state fMRI; no artifacts. Age-matched healthy controls (HC) were recruited from open-source databases. Language laterality was calculated by using task-based fMRI. We obtained the CCN through ad hoc independent component analysis on resting-state fMRI. Differences in CCN between patients and HC were characterized by cosine similarity (CS) and earth mover's distance (EMD). Changes related to language reorganization and patients' speech were assessed with the

resultsOne hundred forty-two right-handed patients (35 low-grade and 88 high-grade gliomas; 19 metastases) and 184 HC were included. Two independent components of the CCN were obtained. The

conclusionsThis study provides evidence that modifications of CCN occur in the setting of language reorganization. Patients exhibiting these modifications perform better at speech evaluation after surgery, suggesting a role of cognitive control in compensating for speech deficits when language reorganizes.

Indexed as

Brain NeoplasmsCognitionLanguageMagnetic Resonance ImagingNerve NetAdultAgedFemaleFunctional LateralityHumansMaleMiddle Aged

Identifiers

PMID39730156
PMCPMC12152808

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.