Evidence map›Paper›PMID 39730001›Full record

Trial reportCell reports. Medicine2025

Mechanism of enhancing chemotherapy efficacy in pancreatic ductal adenocarcinoma with paricalcitol and hydroxychloroquine.

Ganji Purnachandra Nagaraju, Madhu Sudhana Saddala, Jeremy B Foote, Ateeq M Khaliq, Ashiq Masood, Yuvasri Golivi, Dhana Sekhar Reddy Bandi, Sujith Sarvesh, Sudhir Putty Reddy, Jeffrey Switchenko and 10 more

Abstract readClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Ganji Purnachandra NagarajuDepartment of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Madhu Sudhana SaddalaBioinformatics, Genomics and Proteomics, University of California, Irvine, Irvine, CA 92697, USA.
Jeremy B FooteDepartment of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Ateeq M KhaliqIndiana University School of Medicine, Indianapolis, IN 46202, USA.
Ashiq MasoodIndiana University School of Medicine, Indianapolis, IN 46202, USA.
Yuvasri GoliviDepartment of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Dhana Sekhar Reddy BandiDepartment of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Sujith SarveshDepartment of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Sudhir Putty ReddyDepartment of Protein Sciences & Mass Spectrometry, Translational Medicine, Bristol Myers Squibb, Princeton, NJ 08543, USA.
Jeffrey SwitchenkoDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA 30322, USA.
Julienne L CarstensDepartment of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Mehmet AkceDepartment of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Cameron HertingDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
Olatunji B AleseDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
Karina J YoonDepartment of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Upender ManneDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Manoj K BhasinDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA 30322, USA; Department of Pediatrics, Emory University, Atlanta, GA 30322, USA.
Gregory B LesinskiDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
Vikas P SukhatmeDepartment of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA; Department of Medicine, Emory University, Atlanta, GA 30322, USA.
Bassel F El-RayesDepartment of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35233, USA. Electronic address: belrayes@uabmc.edu.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Omer Jamy · 1985 to 2026
$165.9M
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3M
NCI NIH HHS P30 CA013148NCI NIH HHS P30 CA082709
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) has a minimal (<15%) 5-year existence, in part due to resistance to chemoradiotherapy. Previous research reveals the impact of paricalcitol (P) and hydroxychloroquine (H) on altering the lysosomal fusion, decreasing stromal burden, and triggering PDAC to chemotherapies. This investigation aims to elucidate the molecular properties of the H and P combination and their potential in sensitizing PDAC to gemcitabine (G). PH potentiates the effects of G in in vitro, orthotopic mouse models, and a patient-derived xenograft model of PDAC. Proteomic and single-cell RNA sequencing (RNA-seq) analyses reveal that GPH treatment upregulates autophagy and endoplasmic reticulum (ER) stress-related transcripts. GPH treatment decreases the number of Ki67, fibroblast-associated protein (FAP), and alpha-smooth muscle actin (SMA)-expressing fibroblasts with a decrease in autophagy-related transcripts. The GPH treatment increases M1 polarization and CD4

Indexed as

Carcinoma, Pancreatic DuctalErgocalciferolsHydroxychloroquinePancreatic NeoplasmsAnimalsAutophagyCell Line, TumorDeoxycytidineEndoplasmic Reticulum StressFemaleGemcitabineHumansMaleMiceXenograft Model Antitumor AssaysDeoxycytidineErgocalciferolsGemcitabineHydroxychloroquineparicalcitolautophagycancer associated fibroblastschemotherapyhydroxychloroquineimmune cellspancreatic ductal adenocarcinomaparicalcitolproteomicssingle-cell RNA-seq analysesvitamin D receptor

Identifiers

PMID39730001
PMCPMC11866435

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.