Evidence map›Paper›PMID 39729988›Full record

ArticleCurrent biology : CB2025

The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis.

Charles A Day, Florina Grigore, Faruck L Hakkim, Souren Paul, Alyssa Langfald, Molly Weberg, Sela Fadness, Paiton Schwab, Leslie Sepaniac, Jason Stumpff and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Charles A DayThe Hormel Institute, University of Minnesota, Austin, MN 55912, USA; Neuro-Oncology Training Program, Mayo Clinic, Rochester, MN 55905, USA.
Florina GrigoreThe Hormel Institute, University of Minnesota, Austin, MN 55912, USA; Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA.
Faruck L HakkimThe Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Souren PaulThe Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Alyssa LangfaldThe Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Molly WebergThe Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Sela FadnessThe Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Paiton SchwabThe Hormel Institute, University of Minnesota, Austin, MN 55912, USA.
Leslie SepaniacDepartment of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA.
Jason StumpffDepartment of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA; Vermont Cancer Center, University of Vermont, Burlington, VT 05405, USA.
Kevin T VaughanDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; Harper Cancer Center, University of Notre Dame, Notre Dame, IN 46556, USA.
David J DanielsDepartment of Neurosurgery, Mayo Clinic College of Medicine, Rochester, MN 55905, USA; Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN 55905, USA.
James P RobinsonThe Hormel Institute, University of Minnesota, Austin, MN 55912, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: robinsoj@umn.edu.
Edward H HinchcliffeThe Hormel Institute, University of Minnesota, Austin, MN 55912, USA; Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: hinc0002@umn.edu.

Funding

Mechanisms of microtubule motors and chromosome segregationR35GM144133 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI JASON K STUMPFF · 2022 to 2026
$2.4M
Working towards targeted therapy in H3K27M tumors: Aurora Kinase Inhibitors and the role of epigenome programmingR01NS117432 · NINDS · MAYO CLINIC ROCHESTER · PI DANIELS, DAVID · 2020 to 2024
$1.8M
NIGMS NIH HHS R35 GM144133NINDS NIH HHS R01 NS117432
6 · The paper itself

Abstract

Serine 31 is a phospho-site unique to the histone H3.3 variant; mitotic phospho-Ser31 is restricted to pericentromeric heterochromatin, and disruption of phospho-Ser31 results in chromosome segregation defects and loss of p53-dependant G

Indexed as

CarcinogenesisGliomaHistonesMitosisAnimalsCell Line, TumorChromosome SegregationHumansMiceMutationPhosphorylationSerineHistonesSerinecell cycleChk1 kinasechromosome instabilitydiffuse midline gliomaDIPGhistone H3.3K27M mutationp53

Identifiers

PMID39729988
PMCPMC12673919

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.