Evidence map›Paper›PMID 39729649›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2025

Investigating changes in connected speech in nonfluent/agrammatic primary progressive aphasia following script training.

Stephanie M Grasso, Karinne Berstis, Kristin Schaffer Mendez, Willa R Keegan-Rodewald, Lisa D Wauters, Eduardo Europa, H Isabel Hubbard, Heather R Dial, J Gregory Hixon, Maria Luisa Gorno-Tempini and 2 more

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In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stephanie M GrassoDepartment of Speech, Language and Hearing Sciences, University of Texas at Austin, United States. Electronic address: smgrasso@austin.utexas.edu.
Karinne BerstisDepartment of Speech, Language and Hearing Sciences, University of Texas at Austin, United States; Department of Neurology, Dell Medical School, University of Texas at Austin, United States.
Kristin Schaffer MendezDepartment of Speech, Language and Hearing Sciences, University of Texas at Austin, United States; College of Rehabilitative Sciences, The University of St. Augustine for Health Sciences, United States.
Willa R Keegan-RodewaldDepartment of Speech, Language and Hearing Sciences, University of Texas at Austin, United States; West Contra Costa Unified School District, United States.
Lisa D WautersDepartment of Speech, Language and Hearing Sciences, University of Texas at Austin, United States.
Eduardo EuropaMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Department of Communication Sciences and Disorders, California State University, Chico, United States.
H Isabel HubbardDepartment of Speech & Hearing Sciences, University of New Mexico, United States.
Heather R DialDepartment of Speech, Language and Hearing Sciences, University of Texas at Austin, United States; Department of Speech and Hearing, University of Houston, United States.
J Gregory HixonDepartment of Psychology, University of Texas at Austin, United States.
Maria Luisa Gorno-TempiniMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, CA, USA; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Adam VogelHealth Sciences, The University of Melbourne, Redenlab Inc, Australia.
Maya L HenryDepartment of Speech, Language and Hearing Sciences, University of Texas at Austin, United States; Department of Neurology, Dell Medical School, University of Texas at Austin, United States.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Establishing Evidence-based Treatment for Speech and Language in Primary Progressive AphasiaR01DC016291 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2017 to 2021
$3.3M
Bilingual Factors Associated with Cognitive Reserve and Linguistic Resilience in Hispanics with Primary Progressive AphasiaR01AG080470 · NIA · UNIVERSITY OF TEXAS AT AUSTIN · PI Stephanie M Grasso · 2023 to 2026
$2.8M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Rehabilitation of speech and language in primary progressive aphasiaR03DC013403 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI HENRY, MAYA · 2014 to 2016
$565k
NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG080470NIDCD NIH HHS K24 DC015544NIDCD NIH HHS R01 DC016291NIDCD NIH HHS R03 DC013403NINDS NIH HHS R01 NS050915
6 · The paper itself

Abstract

Script training is a speech-language intervention designed to promote fluent connected speech via repeated rehearsal of functional content. This type of treatment has proven beneficial for individuals with aphasia and apraxia of speech caused by stroke and, more recently, for individuals with primary progressive aphasia (PPA). In the largest study to-date evaluating the efficacy of script training in individuals with nonfluent/agrammatic primary progressive aphasia (nfvPPA; Henry et al., 2018), robust treatment effects were observed, with maintenance of gains up to one year post-treatment. However, outcomes were constrained to measures of script accuracy, intelligibility, and grammaticality, providing a limited view of potential treatment benefit to connected speech. The current study evaluated the utility of a broader set of connected speech measures for characterizing script training outcomes in 20 individuals with nfvPPA who were administered Video-Implemented Script Training for Aphasia (VISTA). Probes of trained and untrained script topics from pre- and post-treatment were transcribed, coded, and analyzed using Computerized Language ANalysis (CLAN, MacWhinney, 2000) to extract measures of fluency, grammar, and informativeness. Speech timing measures (e.g., articulation rate, mean pause duration) were derived from audio files. Participants demonstrated significant changes for trained topics from pre-to post-treatment in words per minute, fluency disruptions per hundred words, mean length of utterance in morphemes, grammatical complexity, and proportion of open to closed class words. Reductions were observed in mean and variability of syllable duration and mean pause duration, and speech to pause ratio increased. These findings lend additional support for script training as a means to promote fluency of connected speech in individuals with nfvPPA and illustrate the utility of automated and semi-automated measures for characterizing treatment effects following intervention.

Indexed as

Aphasia, BrocaAphasia, Primary ProgressiveLanguage TherapySpeechSpeech TherapyAgedFemaleHumansMaleMiddle AgedTreatment OutcomeConnected speechNonfluent/agrammatic PPAPrimary progressive aphasiaScript trainingSpeech timing measures

Identifiers

PMID39729649
PMCPMC11995273

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.