ArticleJournal of acquired immune deficiency syndromes (1999)2025
Poorer Longitudinal Growth Among HIV Exposed Compared With Unexposed Infants in Kenya.
Article in Journal of acquired immune deficiency syndromes (1999), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- In-utero HIV exposure and postnatal growth to 8 years of age: a prospective cohort study in the Western Cape, South Africa.The Lancet. Child & adolescent health · 2026Article
- Neurodevelopment of Children Exposed to HIV But Uninfected in Zambia: Outcomes From Prospective Birth Cohort Study.Journal of the International AIDS Society · 2026Observational
- The impact of dolutegravir on the growth of HIV-exposed uninfected infants: an observational cohort study in rural Tanzania.EClinicalMedicine · 2026Article
- Association between infant feeding practices and infant growth by maternal HIV and antiretroviral therapy status: a prospective study in Cape Town, South Africa.BMC pregnancy and childbirth · 2026Article
- Differences in growth trajectories in breastfed HIV-exposed uninfected and HIV-unexposed infants in Kenya: An observational cohort study.PLoS medicine · 2025Observational
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Authors and funding
11 authors.
Funding
Abstract
backgroundMost infants born to women living with HIV are HIV exposed but uninfected exposed infants have poorer growth than HIV-unexposed uninfected children. Few large studies have compared children who are exposed (CHEU) and unexposed (CHUU) in the era of dolutegravir (DTG)-based antiretroviral treatment (ART).
settingLongitudinal study of mother-infant CHEU and CHUU pairs in Nairobi and Western Kenya.
methodsMother-infant pairs were enrolled at 6 weeks postpartum with 6-monthly growth assessments. We compared longitudinal growth between CHEU and CHUU infants during the first year and assessed biologic and social factors affecting growth [length- and weight-for-age z-scores (LAZ, WAZ) and weight-for-length z-scores (WLZ)] and stunting (LAZ <-2), underweight (WAZ <-2), and wasting (WLZ <-2) from birth to 1 year.
resultsAmong 2000 infants (1000 CHEU and 1000 CHUU), CHEU infants had significantly lower LAZ at 6 months {-0.165 [95% confidence interval (CI): -0.274 to -0.056], P -value = 0.003} and 12 months (-0.195, 95% CI: -0.294 to -0.095, P -value = 0.0001; n = 1616). CHEU infants had a higher prevalence of stunting at 6 months compared with CHUU infants (prevalence ratio: 1.45, 95% CI: 1.14 to 1.85). Among all children, greater maternal BMI, education, and caregiver-perceived social support were positively associated with growth. Higher maternal and infant comorbidities were associated with growth deficits for CHEU infants. Among CHEU, ART timing (before versus during pregnancy), and ART regimen (dolutegravir -based, efavirenz-based, and protease inhibitor/other) did not affect growth.
conclusionsGrowth deficits among CHEU persist, despite DTG-based ART. Addressing comorbidities, amplifying social support, and education may improve growth outcomes.
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