Evidence map›Paper›PMID 39729288›Full record

ArticleNeuroradiology2025

Synthetic MRI derived relaxometry parameters: a new insight into characterization of ring enhancing lesions of brain.

Sanket Dash, Sameer Vyas, Nidhi Bhardwaj, Chirag Kamal Ahuja, Manish Modi, Rajesh Chhabra, Jitendra Kumar Sahu, Naveen Sankhyan, Paramjeet Singh

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In one paragraph

Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sanket DashDivision of Neuroimaging and Interventional Neuroradiology, Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Sameer VyasDivision of Neuroimaging and Interventional Neuroradiology, Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. sameer574@yahoo.co.in.ORCID http://orcid.org/0000-0002-0113-0486
Nidhi BhardwajDepartment of Medicine, Govt Medical College & Hospital, Chandigarh, India.
Chirag Kamal AhujaDivision of Neuroimaging and Interventional Neuroradiology, Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Manish ModiDepartment of Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Rajesh ChhabraDepartment of Neurosurgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Jitendra Kumar SahuDepartment of Pediatric Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Naveen SankhyanDepartment of Pediatric Neurology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Paramjeet SinghDivision of Neuroimaging and Interventional Neuroradiology, Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeSynthetic MRI utilizes the quantitative relaxometry parameters to generate multiple contrast images through a single acquisition. We tried to explore the utility of synthetic MRI derived relaxometry parameters in evaluation of ring enhancing lesions of brain. MATERIALS AND

methodsThis was a prospective study. 40 subjects with ring enhancing lesions in brain underwent pre and post contrast synthetic MRI using MDME sequence. Pre and post contrast R1, R2 and PD values were recorded from the core, wall and perilesional edema of lesions and sub group analysis was done among infective, primary neoplastic and secondary neoplastic (metastatic) lesion groups.

resultsPre and post contrast R1, R2 values from core were higher in the infective group compared to the others. Pre and post contrast R1, R2 values were lower in the wall where as it was significantly higher in the perilesional edema of primary neoplastic group. Post-pre the values increased significantly in the perilesional edema of primary neoplasms. R1 value of ≥ 0.689 and R2 value of ≥ 7.481 in the perilesional edema predicts a primary neoplasm over infection with 70.6% sensitivity and 85.7% specificity and over secondary neoplasm with 64.7% sensitivity and 100% specificity.

conclusionSynthetic MRI derived relaxometry parameters in ring enhancing lesions were found to be significantly different across sub groups and can be used to differentiate between primary neoplastic, secondary neoplastic and infective group with parameters from perilesional edema being the most useful.

Indexed as

Brain NeoplasmsImage Interpretation, Computer-AssistedMagnetic Resonance ImagingAdultAgedContrast MediaFemaleHumansMaleMiddle AgedProspective StudiesSensitivity and SpecificityContrast MediaMDMEQuantitative MRIRelaxometryRing-like brain lesionsSynthetic MRITumor

Identifiers

PMID39729288

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.