Evidence map›Paper›PMID 39729186›Full record

Trial reportArchives of osteoporosis2024

Effects of 12-week power training on bone in mobility-limited older adults: randomised controlled trial.

Valentina Muollo, Lars G Hvid, Vikram V Shanbhogue, Viktoria Steinhauser, Daniela Caporossi, Ivan Dimauro, Marianne Skovsager Andersen, Cristina Fantini, Elisa Grazioli, Elsa S Strotmeyer and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Archives of osteoporosis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02051725 (Implementation of an "Active Life-style" Intervention in Older People With Low Physical Function), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02051725 nacompletednot on this map

Implementation of an "Active Life-style" Intervention in Older People With Low Physical Function: Effect on Functional Impairments, Pilot

TypeinterventionalSponsorUniversity of Southern DenmarkRan2013 to 2015Enrolled65ConditionsFunctionally Impaired Elderly, AgingArmsActive life-style intervention
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Associations of muscle strength and functional power with longitudinal change in HR-pQCT bone parameters: the Osteoporotic Fractures in Men (MrOS) Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Valentina MuolloDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. valentina.muollo@univr.it.
Lars G HvidDepartment of Public Health, Exercise Biology, Aarhus University, Aarhus C, Denmark.
Vikram V ShanbhogueDepartment of Endocrinology, Odense University Hospital, Odense, Denmark.
Viktoria SteinhauserDepartment of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Daniela CaporossiDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Ivan DimauroDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Marianne Skovsager AndersenDepartment of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.
Cristina FantiniDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Elisa GrazioliDepartment of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Elsa S StrotmeyerDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Paolo CaserottiDepartment of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.

Funding

Interreg 104-1.5-11
6 · The paper itself

Abstract

This study examines how power training affects estimated bone strength, revealing that females benefit more than males, especially in the upper limbs (radius). These findings highlight the importance of designing sex-specific exercise programs to enhance bone health. Further research is needed to optimize training duration and address site-specific differences. PURPOSE: This study aimed to compare the effects of 12-week of power training (PWT), an explosive form of strength training, on bone microarchitecture, estimated bone strength, and markers in mobility-limited (gait speed < 0.9 m/s) older adults.

methodsFifty-seven older adults (83 ± 5 years) were randomly assigned to either a training group (TRAIN, n = 28, 15 females, 13 males) performing high-intensity PWT or a control group (CTRL, n = 29, 22 females, 7 males) maintaining their usual lifestyle. High-resolution peripheral quantitative computed tomography (HR-pQCT) assessed bone geometry, densities, microarchitecture (e.g. trabecular number (Tb.N) and thickness (Tb.Th)), and estimated bone strength (stiffness and failure load) at the tibia and radius. Blood markers for bone metabolism (PINP and CTX-1) and muscle strength (handgrip and leg press) were also measured.

resultsBaseline sex differences showed females having lower stiffness (- 37.5%) and failure load (- 38%) at the radius compared with males. After PWT, females in the TRAIN group exhibited declines in Tb.N (- 4.4%) and improvements in Tb.Th (+ 6.0%), stiffness (+ 2.7%), and failure load (+ 2.4%) at the radius (p < 0.05). A time x group interaction indicated increases in leg press strength for the whole TRAIN group (+ 23%), and within females (+ 29%) and males (+ 19%) (p < 0.001). Baseline handgrip strength correlated with stiffness (r = 0.577) and failure load (r = 0.612) at the radius (p < 0.001). Females in the TRAIN group showed a reduction in PINP (- 25%), while males showed an increase in CTX-1 (+ 18%).

conclusionA 12-week PWT may enhance estimated bone strength in mobility-limited older adults, especially at sites less accustomed to daily loading (i.e. radius). CLINICAL

trial registrationNCT02051725.

Indexed as

Bone DensityResistance TrainingAgedAged, 80 and overFemaleHumansMaleMobility LimitationProcollagenRadiusTibiaTomography, X-Ray ComputedProcollagenAgingBiochemical markers of bone turnoverBone high-resolution peripheral quantitative computed tomographyExerciseFracture prevention

Identifiers

PMID39729186

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.