Evidence map›Paper›PMID 39729164›Full record

ArticleEJNMMI research2024

Biodistribution and dosimetry of the PET radioligand [

Jordy Akkermans, Alan Miranda, Jeroen Verhaeghe, Filipe Elvas, Franziska Zajicek, Jonathan Bard, Longbin Liu, Vinod Khetarpal, Robert Doot, Steven Staelens and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jordy AkkermansMolecular Imaging Center Antwerp (MICA), Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-1533-9504
Alan MirandaMolecular Imaging Center Antwerp (MICA), Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-5381-015X
Jeroen VerhaegheMolecular Imaging Center Antwerp (MICA), Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.
Filipe ElvasMolecular Imaging Center Antwerp (MICA), Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0001-9790-3369
Franziska ZajicekMolecular Imaging Center Antwerp (MICA), Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.
Jonathan BardCHDI Management, Inc. the Company That Manages the Scientific Activities for CHDI Foundation, Inc., 6080 Center Drive, Suite 700, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5097-1361
Longbin LiuCHDI Management, Inc. the Company That Manages the Scientific Activities for CHDI Foundation, Inc., 6080 Center Drive, Suite 700, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3995-0196
Vinod KhetarpalCHDI Management, Inc. the Company That Manages the Scientific Activities for CHDI Foundation, Inc., 6080 Center Drive, Suite 700, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-2175-5117
Robert DootCHDI Management, Inc. the Company That Manages the Scientific Activities for CHDI Foundation, Inc., 6080 Center Drive, Suite 700, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1747-239X
Steven StaelensMolecular Imaging Center Antwerp (MICA), Universiteitsplein 1, University of Antwerp, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-3376-0519
Daniele BertoglioμNEURO Research Centre of Excellence, Universiteitsplein 1, University of Antwerp, Antwerp, Belgium. daniele.bertoglio@uantwerpen.be.ORCID http://orcid.org/0000-0003-4205-5432

Funding

FWO ID: 1229721NUniversity of Antwerp FFB210050
6 · The paper itself

Abstract

backgroundHuntington's disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related neuropathophysiology. Noninvasive visualization of mHTT aggregates in the brain, with positron emission tomography (PET), will allow to reliably evaluate the efficacy of therapeutic interventions in HD. This study aimed to assess the radiation burden of [

resultsWild-type male and female CD-1 Swiss mice (n = 15/sex) were used to assess in vivo PET imaging-based and ex vivo biodistribution-based tracer distribution of [

conclusionsDosimetry analysis indicated absorbed and effective doses of [

Indexed as

Ex vivo dosimetryHuntington’s diseaseIn vivo dosimetryMousePositron emission tomography

Identifiers

PMID39729164
PMCPMC11680546

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.