Syndecan-1 and E-Cadherin Expression in Canine Cutaneous Squamous Cell Carcinoma.

Rita Files, Cláudia Cardoso, Justina Prada, Filipe Silva, Isabel Pires

Abstract read

In one paragraph

Article in Veterinary sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Comparative pathophysiology and molecular insights into cutaneous and non-cutaneous canine skin cancers: focus on melanoma, mast cell tumors, and squamous cell carcinoma.Frontiers in immunology · 2025
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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Rita FilesDepartment of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.

Cláudia CardosoDepartment of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.

Justina PradaDepartment of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.ORCID 0000-0002-3902-5374

Filipe SilvaDepartment of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.ORCID 0000-0001-6602-0926

Isabel PiresDepartment of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, 5000-801 Vila Real, Portugal.ORCID 0000-0001-6330-4560

Funding

This work was supported by the projects U.I.D.B./00772/2020 (Doi:10.54499/U.I.D.B./00772/2020) funded by the Portuguese Foundation for Science and Technology (F.C.T.). This work was supported by the projects U.I.D.B./00772/2020 (Doi:10.54499/U.I.D.B./00772/2020) funded by the Portuguese Foundation for Science and Technology (F.C.T.).

6 · The paper itself

Abstract

Cutaneous squamous cell carcinoma (CSCC) in dogs is a locally invasive tumor that typically occurs in areas of poorly pigmented skin due to sun exposure. Identifying new biomarkers, such as syndecan-1 (CD138) and E-cadherin, is fundamental for tumor diagnosis and prognosis. Dysregulation of syndecan-1, expressed in epithelial tissue, fibroblasts, and plasma cells, is associated with poor prognosis in several types of cancer. Similarly, E-cadherin, which plays a crucial role in cell adhesion and epithelial functionality, is also linked to adverse outcomes. This study evaluated the expression of syndecan-1 and E-cadherin in 47 cases of canine cutaneous squamous cell carcinoma. The results showed that the intensity of syndecan-1 decreased with increasing tumor aggressiveness, and its presence in the stroma was significantly associated with tumor grade. E-cadherin also demonstrated a decrease in intensity with increasing malignancy. However, the association between syndecan-1 and E-cadherin was not statistically significant. E-cadherin reduction and stromal syndecan-1 positivity seem to be associated with tumor aggressiveness in canine cutaneous squamous cell carcinoma. Further studies are needed to explore their roles in tumor progression.

Indexed as

aggressivenesscutaneous squamous cell carcinomadogsE-cadherinsyndecano-1

Identifiers

PMID39728992

DOI10.3390/vetsci11120652

PMCPMC11680152

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.