Evidence map›Paper›PMID 39728804›Full record

SynthesisToxins2024

Treatment with OnabotulinumtoxinA for Oromandibular Dystonia: A Systematic Review and Meta-Analysis.

Kazuya Yoshida, Ryuji Kaji

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Toxins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kazuya YoshidaDepartment of Oral and Maxillofacial Surgery, National Hospital Organization, Kyoto Medical Center, Kyoto 612-8555, Japan.ORCID 0000-0002-2985-4347
Ryuji KajiDepartment of Neurology, Tokushima University, Tokushima 770-8503, Japan.ORCID 0000-0001-6207-1080

Funding

the Japan Society for the Promotion of Science (JSPS) KAKENHI (JP24592946, JP22111201, and JP22K10091)
6 · The paper itself

Abstract

Oromandibular dystonia (OMD) is a focal dystonia characterized by contractions of the masticatory, lingual, and other muscles of the stomatognathic system. We conducted a systematic review and meta-analysis to elucidate the impact and safety of botulinum toxin in OMD. The eligibility criteria were full-length original articles that provided data evaluating the efficacy and adverse effects of onabotulinumtoxinA injections in patients with OMD. PubMed and Embase were searched for articles published before 31 May 2023. We analyzed cases that showed a favorable response (>0% improvement), moderate or greater response (>50% improvement), and adverse effects. A fixed-model meta-analysis of 26 studies involving 1103 patients revealed that an overall favorable effect of onabotulinumtoxinA injection was observed in 96.2% (95% confidence interval [CI], 95-97.5%,

Indexed as

Botulinum Toxins, Type ADystonic DisordersHumansNeuromuscular AgentsTreatment OutcomeBotulinum Toxins, Type ANeuromuscular Agentsonabotulinum toxin Aadverse effectbotulinum toxinbotulinum toxin therapyimprovementmasticatory musclemeta-analysisonabotulinumtoxinAoromandibular dystoniasafetysystematic review

Identifiers

PMID39728804
PMCPMC11679302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.