Evidence map›Paper›PMID 39728506›Full record

ArticleMetabolites2024

Reduced Intra- and Extracellular Circulating Postprandial Lysosomal Acid Lipase Activity in Patients with MASLD.

Monica Mischitelli, Eleonora Poggiogalle, Giulia Tozzi, Flaminia Ferri, Simona Parisse, Benedetta Meloni, Anna Morrone, Alice Sabbadini, Monther Salem, Elena Gangitano and 5 more

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In one paragraph

Article in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Monica MischitelliDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1865-4101
Eleonora PoggiogalleDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Giulia TozziDivision of Metabolic Diseases, Bambino Gesù Children's Hospital IRCCS, 00146 Rome, Italy.ORCID 0000-0002-1745-2797
Flaminia FerriDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-8553-5589
Simona ParisseDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-9953-009X
Benedetta MeloniDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Anna MorroneDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Alice SabbadiniDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Monther SalemDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Elena GangitanoDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-1044-2278
Adriano De SantisDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-7338-9203
Giulia d'AmatiDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-6959-691X
Lucio GnessiDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-8217-2372
Lorenzo Maria DoniniDepartment of Experimental Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0003-4692-4754
Stefano Ginanni CorradiniDepartment of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-0839-1961

Funding

Alexion, AstraZeneca Rare Disease ISR 200108Italian Ministero dell'Istruzione e del Merito 2015JSWLTN
6 · The paper itself

Abstract

BACKGROUND/

objectivesLow fasting blood lysosomal acid lipase (LAL) activity is associated with the pathogenesis of metabolic hepatic steatosis. We measured LAL activity in blood and plasma before and after an oral fat tolerance test (OFTT) in patients with metabolic-dysfunction-associated steatotic liver disease (MASLD).

methodsTwenty-six controls and seventeen patients with MASLD but without diabetes were genotyped for the patatin-like phospholipase 3 (PNPLA3) rs738409 variant by RT-PCR and subjected to an OFTT, measuring LAL activity in blood and plasma with a fluorimetric method.

resultsLAL activity in blood both under fasting and 4 h after OFTT (0.846 ± 0.309 nmol/spot/h vs. 1.180 ± 0.503 nmol/spot/h

conclusionsPatients with MASLD have reduced LAL activity in blood and plasma both before and 4 h after a meal. In patients with MASLD, the physiological negative correlation between circulating LAL levels and postprandial hypertriglyceridemia is lost.

Indexed as

lysosomal acid lipasemetabolic dysfunctionmetabolic flexibilityPNPLA3 polymorphism

Identifiers

PMID39728506
PMCPMC11679640

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