Evidence map›Paper›PMID 39728428›Full record

ArticleMetabolites2024

Metabolic Aging as an Increased Risk for Chronic Obstructive Pulmonary Disease.

Claire J Guo, Suneeta Godbole, Wassim W Labaki, Katherine A Pratte, Jeffrey L Curtis, Robert Paine, Eric Hoffman, Meilan Han, Jill Ohar, Christopher Cooper and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Claire J GuoDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Suneeta GodboleDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-7358-2078
Wassim W LabakiDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Katherine A PratteDivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO 80206, USA.
Jeffrey L CurtisDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0001-5191-4847
Robert PaineDivision of Respiratory, Critical Care and Occupational Medicine, University of Utah, Salt Lake City, UT 84132, USA.
Eric HoffmanDepartment of Radiology, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-8456-9437
Meilan HanDivision of Biostatistics and Bioinformatics, National Jewish Health, Denver, CO 80206, USA.
Jill OharSection of Pulmonary, Critical Care, Allergy and Immunologic Diseases, Department of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC 27101, USA.
Christopher CooperDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Katerina J KechrisDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-3725-5459
Dawn L DeMeoChanning Division of Network Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Russell P BowlerGenomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44106, USA.ORCID 0000-0003-4651-363X

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
GENETIC EPIDEMIOLOGY OF COPD (COPD GENE) TASK A: STUDY VISIT 4, COLLECTION OF COPDGENE STUDY DATA ANDBIOSPECIMENS AND OVERSIGHT OF THE COPDGENE STUDY75N92023D00011 · NHLBI · NATIONAL JEWISH HEALTH · PI NEWMAN, LEE S · 2023 to 2025
$29.6M
SPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9M
Respiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Understanding the Origins of Early COPDR01HL144718 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CURTIS, JEFFREY LOUIS, HAN, MEILAN K · 2020 to 2024
$11.3M
SPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2M
Networks Tools to Understand Sex- and Gender-Specific Drivers of DiseaseR01HG011393 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L, QUACKENBUSH, JOHN · 2021 to 2024
$2.1M
Leveraging Serum Metabolomics to Understand Clinical Phenotypes in COPDK23HL151751 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LABAKI, WASSIM W · 2020 to 2024
$875k
Mentoring in Patient Oriented Research in Lung Disease through the Lens of Sex as a Biological VariableK24HL171900 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DAWN L DEMEO · 2024 to 2026
$386k
Preclinical Services for Biopharmaceutical Product Development75N93023D00011 · NIAID · ALLUCENT GOVERNMENT SERVICES (US) LLC · 2023 to 2023
$7k
CLC NIH HHS 75N90023D00011NHGRI NIH HHS R01 HG011393NHLBI NIH HHS 75N92021D00011NHLBI NIH HHS 75N92023D00011NHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS K23 HL151751NHLBI NIH HHS K24 HL171900NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL144718NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIAID NIH HHS 75N93023D00011NIH HHS 1X01HL153656-01A1
6 · The paper itself

Abstract

BACKGROUND/

objectivesBoth aging and chronic obstructive pulmonary disease (COPD) are strongly associated with changes in the metabolome; however, it is unknown whether there are common aging/COPD metabolomic signatures and if accelerated aging is associated with COPD.

methodsPlasma from 5704 subjects from the Genetic Epidemiology of COPD study (COPDGene) and 2449 subjects from Subpopulations and intermediate outcome measures in COPD study (SPIROMICS) were profiled using the Metabolon global metabolomics platform (1013 annotated metabolites). Post-bronchodilator spirometry measures of airflow obstruction (forced expiratory volume at one second (FEV

resultsOur metabolic age score was strongly associated with chronic age in the validation cohort (correlation coefficient = 0.8). COPD subjects with accelerated aging (>7 years difference between metabolic and actual age) had more severe disease compared with those who had decelerated aging (<-7 years difference between metabolic and actual age). COPD and aging metabolites were shared more than expected (

conclusionsThese findings suggest a common mechanism between aging and COPD and that COPD is associated with accelerated metabolic aging.

Indexed as

agingCOPDmetabolic age

Identifiers

PMID39728428
PMCPMC11677693

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.